Description
Product Characteristics:
NHE-3 are integral membrane proteins that are expressed in most mammalian tissues, where they regulate intracellular pH and cell volume. NHEs mediate the transport of hydrogen (H+) ions out of cells in exchange for extracellular sodium (Na+) ions. While NHE-1 is ubiquitously expressed, the NHE isoforms 2-8 have distinct tissue- and cell type-dependent expression and inhibitory characteristics. NHE-3 localizes to the apical membrane of renal proximal tubules where it is responsible for most of the sodium transport and fluid reabsorption. NHE-3 translocates to internal pools where it mediates natriuresis when blood pressure increases abruptly. NHE-3 is also expressed in the stomach and functions to protect the mucosa by secreting protons that diffuse into the mucous cells.
Subcellular location: Cell membrane
Synonyms: Na+/H+ exchanger 3, NHE 3, NHE-3, NHE3, SL9A3_HUMAN, SLC9A 3, Sodium, Slc9a3, Sodium/hydrogen exchanger 3, Sodium/hydrogen exchanger, apical epithelial, Solute carrier family 9 sodium/hydrogen exchanger, isoform 3, Solute carrier family 9 sodium/hydrogen exchanger, member 3, Solute carrier family 9 member 3, MGC126718, MGC126720.
Target Information: displays Na+/H+ exchanger transport activity\, mediates sodium ion transport across the renal proximal tubule [RGD, Feb 2006]