Fig 1: KPC mice and KPPC mice show nerve fiber hypertrophy and increased fiber density. (A). Human pancreatic cancer specimen with nerve fiber hypertrophy and increased nerve fiber density; Asterisk = Nerve; Arrow = PDAC (Scale bar = 100 µm in low magnification and 40 µm in high magnification). (B–D). Representative images of neuronal structures (Anti-beta-Tub III) in control (B), KPC mice (B) and KPPC mice ((D); scale bar = 100 µm). (E,F). Co-stating of PGP 9.5 (neuronal marker) with panCK (marker for PDAC) in tissue from KPC mice. (G), H&E staining in KPPC tissue showing cancer cells (arrows) invading the neuronal compartment (asterisk). Scale bar: 100 µm in low magnification and 10 µm in high magnification.