Fig 1: Expression of ADAMTS versicanases in healthy and dystrophic muscles. Representative images of ADAMTS-1, ADAMTS-5 and ADAMTS-15 immunoreactivity (red) and nuclei (blue). ADAMTS-1 immunoreactivity in TA muscle cross-sections from mdx (A–C) and C57/BL10 (D–F) mice. ADAMTS-5 immunoreactivity in TA muscle cross-sections from mdx (G–I) and C57/BL10 (J–L) mice, where ADAMTS-5 was found to be highly expressed in the endomysium (white arrow) and within areas of mononuclear infiltrate (white arrowhead). ADAMTS-15 immunoreactivity in TA muscle cross-sections from mdx (M–O) and C57/BL10 (P–R) mice. (S) Quantitation of ADAMTS versicanase immunoreactivity demonstrated increased Adamts-5 expression in TA muscles from mdx mice. *P < 0.05; independent t-test. N = 5 C57BL/10 mice and n = 5 mdx mice. Scale bar = 100 µm.