Description
Product Characteristics:
Mitogen activated protein kinase kinase 6 (MEK6 or MKK6) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MEK6, closely related to MEK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38, thus activating it, in response to inflammatory cytokines and environmental stress.As an essential component of p38 MAP kinase mediated signal transduction pathway, this protein is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
Subcellular location: Cytoplasm, Nucleus
Synonyms: MAP kinase kinase 6, MAPK/ERK kinase 6, MAPKK6, MEK6, Mitogen Activated Protein Kinase Kinase 6, MKK 6, MKK6, PRKMK6, SAPKK3, Dual specicity mitogen activated protein kinase kinase 6, MKK 6, Dual specicity mitogen activated protein kinase kinase 6, EC 2.7.12.2, MP2K6_HUMAN.
Target Information: This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]