Description
Product Characteristics:
Feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation. Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK without inhibiting cytoplasmic phosphorylation of ERK. Mediates JNK activation and may be involved in apoptosis.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: Interleukin-17 receptor D, IL17RD, DKFZp434N1928, FLJ35755, hSef, IL 17 receptor D, IL 17RD, IL17 receptor D, IL17Rhom, IL17RLM, Interleukin 17 receptor D, Interleukin 17 receptor like protein, Interleukin17 receptor D, MGC133309, SEF, Sef homolog, I17RD_HUMAN.
Target Information: This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin (PMID: 19079364). The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling (PMID: 21663947, 18096367). [provided by RefSeq, Nov 2011]