Description
Product Characteristics:
postsynaptic density protein 95 is a molecular scaffolding protein that binds and clusters N-methyl-D-aspartate receptors at neuronal synapses, may be involved in guanine nucleotide-mediated signal transduction pathway. This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with DLG2. With DLG2 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: Discs large homolog 4, DLG 4, DLG4, Human post-synaptic density protein 95, Postsynaptic density protein 95, PSD 95, PSD-95, SAP 90, SAP90, Synapse associated protein 90.
Target Information: This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]