Description
Product Characteristics:
PFKFB1 belongs to the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. It forms a homodimer that is involved in both the synthesis and degradation of fructose 2,6-bisphosphate. The activity of this enzyme is thought to regulate glucose homeostasis.
Subcellular location: Cytoplasm
Synonyms: 6 phosphofructo 2 kinase/fructose 2 6 biphosphatase 1, 6-bisphosphatase, 6-P2ase 1, 6-P2ASE liver isozyme, 6PF 2 K/Fru 2 6 P2ASE liver isozyme, 6PF 2 K/Fru 2,6 P2ase 1, 6PF-2-K/Fru-2, F261_HUMAN, F6PK, Fructose 2 6 bisphosphatase, Fructose 6 phosphate 2 kinase:fructose 2 6 bisphosphatase, Fructose-2, HL2K, MGC116715, MGC116717, PFK/FBPase 1, PFKFB 1, Pfkfb1, PFRX.
Target Information: This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]