Description
Product Characteristics:
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein(APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq].
Subcellular location: Cell membrane
Synonyms: BACE1 Ser498, BACE1 S498, p-BACE1 Ser498, p-BACE1 Se498, APP beta secretase, Asp 2, ASP2, Aspartyl protease 2, BACE 1, BACE, Beta secretase 1, Beta secretase, Beta site amyloid beta A4 precursor protein cleaving enzyme, Beta site amyloid precursor protein cleaving enzyme 1, Beta site amyloid precursor protein cleaving enzyme, Beta site APP cleaving enzyme 1, Beta site APP cleaving enzyme, FLJ90568, HSPC104, KIAA1149, Memapsin-2, Memapsin 2, Memapsin2, Membrane associated aspartic protease 2, Transmembrane aspartic proteinase Asp2, BACE1_HUMAN, Beta-secretase 1, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Membrane-associated aspartic protease 2.
Target Information: Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]