Description
Product Characteristics:
Tissue specificity: Liver, skeletal and heart muscle, mammary cells. Very low levels in brain, lung, placenta and kidney. Strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. Overexpresseed in 80 % of colorectal cancers.
Subcellular location: Nucleus
Synonyms: Only zinc finger protein,OZF,OZF_HUMAN,Zfp146,Zinc finger protein 146,Zinc finger protein OZF,ZNF146,MGC125660,MGC125661.
Target Information: Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator