Fig 1: Alterations occur in endocrine cells in CA-PKA corpus A–H, Images of corpus and antrum sections from 6-week- and 12-month-old control and CA-PKA mice co-stained with pan-endocrine cell marker chromogranin A (CHGA) (red) and GSII-lectin (green). In the corpus (A) and antrum (C) of 6-week-old control mice, CHGA+ (white arrowhead) and GSII+ (white arrow) cells are indicated. In the corpus (B) and antrum (D) of 6-week-old mutants, the CHGA population (red arrowheads) was unaffected, whereas hyperplasia of GSII+ (red arrows) (in mutant corpus) can be seen. In the corpus (E) of 12-month-old control mice, CHGA+ (white arrowhead) and GSII+ (white arrow) cells are indicated. In the corpus of 12-month-old CA-PKA mice (F) CHGA+ (red arrows) population was decreased. In the antrum (G) of 12-month-old control mice, CHGA+ (white arrowhead) and GSII+ (white arrow) cells are indicated. In the antrum (H) of 12-month-old mutants, the CHGA+ population (red arrowheads) was unaffected. Scale bars = 50 µm.