Anti-RRM2 antibody [1E1] ab57653 from Abcam

Product Specs
ItemAnti-RRM2 antibody [1E1]
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab57653
Antibody TypePrimary
Quantity100 UG
ApplicationsFlow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot
HostMouse, Nude mouse
ClonalityMonoclonal
IsotypeIgG1
Conjugate/TagUnconjugated
Concentration0.5 mg/ml
Clone10
Gene Namerrm2
ReactivityHuman
TargetRRM2

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Radiation-Induced Cellular Senescence Reduces Susceptibility of Glioblastoma Cells to Oncolytic Vaccinia VirusCancers (Basel)June 25, 2023Quinn T. Storozynsky, Xuefei Han, Shae Komant, Kate C. Agopsowicz, Kyle G. Potts, Armin M. Gamper, Roseline Godbout, David H. Evans, Mary M. Hittanti-p21 (1:1000; ab109520, Abcam, Cambridge, UK), anti-TK1 (1:500; ab59271, Abcam), anti-RRM2 (1:500; ab57653, Abcam), anti-p53R2 (1:1000; ab8105 [Abcam]), anti-β-tubulin (1:1000; 2146, Cell Signaling Technologies,

(2) MiR-202-3p inhibits the proliferation and metastasis of lung adenocarcinoma cells by targeting RRM2Annals of Translational MedicineDecember 1, 2022Xiaowen Cao, Fangsu Xue, Haoyu Chen, Lu Shen, Xiaosa Yuan, Yunchi Yu, Ying Zong, Lou Zhong, Fang HuangAll-in-one RT SuperMix Perfect for qPCR were purchased from Nanjing Vazyme Biotech Co., Ltd. The RRM2 (ab57653) and β-actin (ab8226) antibodies were purchased from Abcam (USA), and the goat anti-mouse secondary

(3) LncRNA HOTAIR facilitates proliferation and represses apoptosis of retinoblastoma cells through the miR-20b-5p/RRM2/PI3K/AKT axisOrphanet Journal of Rare DiseasesDecember 1, 2022Ke Fu, Ke Zhang, Xiaoyu ZhangMA, USA), Cleaved Caspase-3 (20 µg/mL, ab32042, Abcam), Bcl-2 (1/500, ab692, Abcam), RRM2 (1 µg/mL, ab57653, Abcam, Cambridge, MA, USA), AKT (1/500, ab8805, Abcam), phosphorylated AKT (p-AKT, 1/500, ab38449,

(4) MiR ‐200c‐3p and miR ‐485‐5p overexpression elevates cisplatin sensitivity and suppresses the malignant phenotypes of non–small cell lung cancer cells through targeting RRM2Thoracic CancerJuly 1, 2022Ying Liu, Yong Zhang, Qiubo Li, Ruiqi Xu, Nian Huang(BSA) to seal the non‐specific binding sites and probed with primary antibodies, containing anti‐RRM2 (ab57653) (Abcam) and anti‐GAPDH (ab9485) (Abcam). The immunoblots were then probed with horseradish peroxidase

(5) Oxymatrine induces anti-tumor response in cervical cancer by modulating circ_0008460/miR-197-3p/ribonucleotide reductase subunit M2 (RRM2)BioengineeredMay 24, 2022Siwei Li, Heng Zhang, Yunping Jiao, Xiao Song, Lei Wei, Xing LiuBcl-2-associated X (Bax; Abcam, ab32503, 1:1000), cleaved-caspase-3 (Abcam, ab2302, 1:1000), RRM2 (Abcam, ab57653, 1:1000), and GAPDH (Abcam, ab181602, 1:3000). Goat anti-rabbit/mouse IgG H&L (HRP) secondary antibody

(6) Construction of a Novel Ferroptosis-Related Gene Signature for Predicting Survival of Patients With Lung AdenocarcinomaFrontiers in oncologyJanuary 1, 2022Song X, Wu L, Wang G, Liu B, Zhu W.MIF (ab65869, Abcam, Cambridge, MA, USA), PANX1 (12595-1-AP, Proteintech, Wuhan, China), and RRM2 (ab57653, Abcam). The primary antibody of EGLN1 was diluted at 1:100, others were diluted at 1:200 and incubated

(7) Anti-Tumor Effect of Apatinib and Relevant Mechanisms in LiposarcomaFrontiers in OncologyNovember 18, 2021Lixuan Cui et al.in the subsequent experiments. Anti-CD34 (No. ab81289), anti-RRM2(No. ab108995), and anti-TYMS (No. ab57653) were obtained from Abcam, Cambridge, UK. Anti-STAT3(No. 4904T), anti-p-STAT3(No.9145T),anti-AKT(No.4691T),anti-p-AKT(No.4060T),anti-mTOR(No.2983T),anti-p-mTOR(No.5536T),anti-PD-L1(No.13684S),anti-PI3K(No.

(8) Novel Insights into the Molecular Regulation of Ribonucleotide Reductase in Adrenocortical Carcinoma TreatmentCancers (Basel)August 20, 2021Christina Bothou, Ashish Sharma, Adrian Oo, Baek Kim, Pal Perge, Peter Igaz, Cristina L. Ronchi, Igor Shapiro, Constanze Hantelconducted according to the protocol for immunohistochemistry. Primary anti-RRM2 mouse MAB was used (#ab57653, Abcam, Cambridge, UK) at a 2.5 mg/mL dilution overnight at 4 °C. The secondary antibody was used at

(9) Proteomic Reveals Reasons for Acquired Drug Resistance in Lung Cancer Derived Brain Metastasis Based on a Newly Established Multi-Organ Microfluidic Chip ModelFrontiers in Bioengineering and BiotechnologyDecember 22, 2020Mingxin Xu, Yingyan Wang, Wenzhe Duan, Shengkai Xia, Song Wei, Wenwen Liu, Qi Wangwith primary antibodies against GPX4 (1:1,000 dilution; ab125066, Abcam, UK), RRM2 (1:1,000 dilution; ab57653, Abcam, UK), GCLC (1:1,000 dilution; ab190685, Abcam, UK), GPX1 (1:1,000 dilution; ab108427, Abcam,

(10) RRM2 protects against ferroptosis and is a tumor biomarker for liver cancerCancer cell internationalDecember 7, 2020Yang Y, Lin J, Guo S, Xue X, Wang Y, Qiu S, Cui J, Ma L, Zhang X, Wang J.Technology (CST), Boston, MA, USA, #5174 or #51332), anti-RRM2 (Abcam, Hong Kong, China, #ab172476 and #ab57653), anti-CBS (Abcam, #ab140600), anti-CTH (Abcam, #ab189916), anti-SHMT2 (Abcam, #ab180786), anti-GPX4

(11) LncRNA TTN-AS1 Regulates miR-524-5p and RRM2 to Promote Breast Cancer ProgressionOncoTargets and TherapyMay 27, 2020Hui Feng, Qi Wang, Wenjing Xiao, Biyuan Zhang, Yonglong Jin, Haijun LuMA, USA) and blocked with 5% skim milk for 1 h. After incubated with primary antibodies anti-RRM2 (ab57653, Abcam, 1:1000), antiSurvivin antibody (ab76424, Abcam, 1:1000) and antiGAPDH (ab8245, Abcam, 1:1000)

(12) RRM2 elicits the metastatic potential of breast cancer cells by regulating cell invasion, migration and VEGF expression via the PI3K/AKT signalingOncology lettersApril 1, 2020Zhuang S, Li L, Zang Y, Li G, Wang F.(Corning, Inc.). All protocols were Antibodies. Mouse monoclonal antibodies to human RRM2 (cat. no. ab57653) and rabbit monoclonal antibodies to human MMP‑2 antibodies (cat. no. ab92536) were purchased from Abcam.

(13) Knockdown of lncRNA KCNQ1OT1 inhibits glioma progression by regulating miR-338-3p/RRM2Open Life SciencesMarch 12, 2020Zhangxing Yin, Liqing Liao, Sheng Mao, Ying Liu, Tao Xie, Hua Yu, Wenxu Zhaowestern blocking buffer (Beyotime) and then incubated with the following primary antibodies against RRM2 (ab57653, 1:100 dilution, Abcam, Cambridge, MA, USA), PCNA (ab152112, 1:3000 dilution, Abcam), KCNQ1OT1 regulates

(14) Cyclin F is involved in response to cisplatin treatment in melanoma cell linesOncology reportsMarch 1, 2020Krajewski A, Gagat M, Żuryń A, Hałas-Wiśniewska M, Grzanka D, Grzanka A.antibodies were used: Cyclin F (cat. no. sc-515207; 1:100, Santa Cruz Biotechnology Inc.). RRM2 (cat. no. ab57653; 1:200, Abcam), p53 (Pab 240; cat. no. 13-4100; 1:100), p-ATR (cat. no. 720107; 1:200), p-H2.AX (cat.

(15) Downregulation of RRM2 Attenuates Retroperitoneal Liposarcoma Progression via the Akt/mTOR/4EBP1 Pathway: Clinical, Biological, and Therapeutic SignificanceOncoTargets and therapyJanuary 1, 2020Zhang S, Yan L, Cui C, Wang Z, Wu J, Lv A, Zhao M, Dong B, Zhang W, Guan X, et al.Beijing, China) was used to block the slices. The slices were incubated with RRM2 antibody (1:800, ab57653, Abcam, Cambridge, MA, USA) and secondary antibody working fluid (PV-6000, Beijing Zhongshan Golden

(16) Clofarabine Commandeers the RNR-α-ZRANB3 Nuclear Signaling AxisCell Chemical BiologyJanuary 1, 2020Marcus J.C. Long, Yi Zhao, Yimon Aye60073-1-Ig (Ms), Proteintech, 1:2000 (WB), 1:200 (IF), 1:300 (PLA for both HeLa and U2OS cells)]; RNR-β [AB57653 (Ms), AbCam, 1:1000 (WB), 1:200 (IF)]; BrdU [NA61, Calbiochem, 1:1000 (Clone MoBu-1, DPA, selective

(17) Cyclin F Downregulation Affects Epithelial-Mesenchymal Transition Increasing Proliferation and Migration of the A-375 Melanoma Cell LineCancer management and researchJanuary 1, 2020Krajewski A, Gagat M, Mikołajczyk K, Izdebska M, Żuryń A, Grzanka A.(ThermoFisher, M1-154), cyclin B (ThermoFisher, MA5-14,319), cyclin D (Sigma-Aldrich, SAB4502603), RRM2 (Abcam, ab57653), p53 (ThermoFisher, Pab 240), NFkB p65 (ThermoFisher, 33–9900), vimentin – immunofluorescence (Abcam,

(18) Super-Enhancer-Associated Hub Genes In Chronic Myeloid Leukemia Identified Using Weighted Gene Co-Expression Network AnalysisCancer Management and ResearchDecember 23, 2019Hongying Ma, Jian Qu, Jian Luo, Tingting Qi, Huanmiao Tan, Zhaohui Jiang, Haiwen Zhang, Qiang Qu

(19) RRM2 Regulated By LINC00667/miR-143-3p Signal Is Responsible For Non-Small Cell Lung Cancer Cell ProgressionOncoTargets and TherapyNovember 20, 2019Yanbing Yang, Sensen Li, Juan Cao, Yaojun Li, Haiying Hu, Zhuyu Wuat room temperature and incubated with primary antibodies at 4°C overnight, including RRM2 (1:1000, ab57653, Abcam), Cyclin A1 (1:1000, ab53699, Abcam), Cyclin B1 (1:1000, ab72, Abcam), CDK2 (1:1000, ab32174,

(20) Knockdown of ribonucleotide reductase regulatory subunit M2 increases the drug sensitivity of chronic myeloid leukemia to imatinib‑based therapyOncology ReportsJune 11, 2019Chunshui Liu, Yuying Li, Ruiping Hu, Wei Han, Sujun GaoTBST at 37°C for 1 h and incubated with primary antibodies including: RRM2 (dilution 1:1,000, cat. no. ab57653; Abcam, Shanghai, China), Bcl-2 (dilution 1:1,000; cat. no. ab59348; Abcam), Bax (dilution 1:1,000;

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Anti-RRM2 antibody [1E1] from Abcam

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Anti-RRM2 antibody [1E1] from Abcam

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