Anti-Mitofusin 2 antibody [6A8] ab56889 from Abcam

Product Specs
ItemAnti-Mitofusin 2 antibody [6A8]
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab56889
Antibody TypePrimary
IsotypeIgG2a
HostMouse, Nude mouse
Quantity50 UG
ApplicationsFlow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot
ClonalityMonoclonal
Conjugate/TagUnconjugated
Concentration0.5 mg/ml
Clone6A8
Research AreaNeuroscience
Gene NameMFN2
ReactivityHuman, Mouse
TargetMitofusin 2

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Selective induction of Rab9-dependent alternative mitophagy using a synthetic derivative of isoquinoline alleviates mitochondrial dysfunction and cognitive deficits in Alzheimer's disease modelsTheranosticsJanuary 1, 2024Jee-Hyun Um, Dong Jin Shin, Se Myeong Choi, Alen Benhur Pravin Nathan, Young Yeon Kim, Da Ye Lee, Dae Jin Jeong, Dong Hyun Kim, Kyung Hwa Kim, Young Hye Kim, et al.and subjected to western blot analysis as described previously 51. Anti-Cox2 (ab198286), anti-MFN2 (ab56889), anti-SDHB (ab14714), anti-P4HB (ab137110), anti-PMP70 (ab3421), anti-PGC-1α (ab191838), anti-TFAM

(2) AMPKα1 negatively regulates osteoclastogenesis and mitigates pathological bone lossJournal of Biological ChemistryDecember 1, 2023Mariana S.P. Ribeiro, Lucas G.R. Venturini, Cesar A. Speck-Hernandez, Paulo V.G. Alabarse, Thais Xavier, Thaise M. Taira, Letícia F. Duffles, Fernando Q. Cunha, Sandra Y. Fukadaanti-pAMPKα1 (PA517831) (Thermo Fisher), anti-cathepsin K (ab66237), anti-NFAT2 (ab2796), anti-Mfn2 (ab56889), antibeta actin (ab8226) (Abcam), and anti-DC-STAMP (clone 1A2, catalog no.: MABF39-I) (Merck KgaA)

(3) The Natural Alkaloid Palmatine Selectively Induces Mitophagy and Restores Mitochondrial Function in an Alzheimer’s Disease Mouse ModelInternational Journal of Molecular SciencesNovember 20, 2023Da-Ye Lee, Kang-Min Lee, Jee-Hyun Um, Young-Yeon Kim, Dong-Hyun Kim, Jeanho Yunwestern blot analysis as described previously. Anti-Cox2 (ab198286), anti-SDHB (ab14714), anti-MFN2 (ab56889), anti-PGC-1α (ab191838), anti-NRF1 (ab175932), and anti-TFAM (ab272885) antibodies were purchased from

(4) The obesity‐linked human lncRNA AATBC stimulates mitochondrial function in adipocytesEMBO reportsOctober 9, 2023Maude Giroud, Stefan Kotschi, Yun Kwon, Ophélia Le Thuc, Anne Hoffmann, Manuel Gil‐Lozano, Michael Karbiener, Juan Carlos Higareda‐Almaraz, Sajjad Khani, Daniel Tews, et al.Mfn2,ab56889 (Abcam) OXPHOS,ab110413 (Abcam) Opa1,ab42364 (Abcam) β‐tubulin,2146S (Cell Signaling Technology) TOMM20,ab78547

(5) E4 ubiquitin ligase promotes mitofusin turnover and mitochondrial stress responseMol CellAugust 17, 2023Vincent Anton, Ira Buntenbroich, Tânia Simões, Mariana Joaquim, Leonie Müller, Reinhard Buettner, Margarete Odenthal, Thorsten Hoppe, Mafalda Escobar-Henriquesantibodies were used in this study: anti-Fzo1 (rabbit; 1:1000; GenScript33), anti-MFN2 (mouse; 1:1000; #ab56889; Abcam), anti-MFN1 (mouse; 1:1000; also recognizes MFN2; #H00055669-M04; Abnova), anti-Ufd2 (rabbit;

(6) IPSC derived cardiac fibroblasts of DMD patients show compromised actin microfilaments, metabolic shift and pro-fibrotic phenotypeBiology DirectJuly 27, 2023Salwa Soussi, Lesia Savchenko, Davide Rovina, Jason S. Iacovoni, Andrea Gottinger, Maxime Viallettes, Josè-Manuel Pioner, Andrea Farini, Sara Mallia, Martina Rabino, et al.,Cell Signaling Technology,#12165 LDHA,Santa Cruz Biotechnology,sc-137243 LDHB,Santa Cruz Biotechnology,sc-100775 MFN2,Abcam,ab56889 Oxphos,Invitrogen,45-8099 PDHE1a,Santa Cruz Biotechnology,sc-377092 Phospho PDHE1a,Cell Signaling Technology

(7) Abnormal expression of fission and fusion genes and the morphology of mitochondria in eutopic and ectopic endometriumEuropean Journal of Medical ResearchJuly 1, 2023Chaoshuang Ye, Pei Chen, Bingning Xu, Yang Jin, Yongchao Pan, Tianyu Wu, Yongjiang Du, Jingxia Mao, Ruijin WuAbcam, USA), OPA1 (1:100, 612606, BD bioscience, USA), MFN1 (1:500, ab57602, Abcam, USA), MFN2 (1:200, ab56889, Abcam, USA), LCLAT1 (1:400, ab153987, Abcam, USA) were applied at 4 °C overnight. Then each section

(8) Regulation of mitochondrial morphology and cristae architecture by the TLR4 pathway in human skeletal muscleFrontiers in Cell and Developmental BiologyJune 26, 2023Mauricio Castro-Sepulveda, Mauro Tuñón-Suárez, Giovanni Rosales-Soto, Ronald Vargas-Foitzick, Louise Deldicque, Hermann Zbinden-FonceaPVDF membranes. The following antibodies were used: Mfn1 (sc-166644-Santa Cruz Biotechnology), Mfn2 (ab56889-Abcam), Opa1 (612606-BD-Biosciences), TLR4 (sc-293072-Santa-Cruz-Biotechnology), Drp1 (sc-101270-Santa-Cruz-Biotechnology),

(9) Impaired mitochondrial dynamics and removal of the damaged mitochondria in diabetic retinopathyFront Endocrinol (Lausanne)June 21, 2023Kumari Alka, Jay Kumar, Renu A. Kowlurubuffer and Mfn2 was immunoprecipitated from 100μg lysate using 3μg Mfn2 monoclonal antibody (Cat. No. ab56889, Abcam, Cambridge, MA). The pellet was incubated with Protein A/G Plus agarose beads suspended in the

(10) Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoAThe EMBO journalJune 1, 2023Ngo J, Choi DW, Stanley IA, Stiles L, Molina AJA, Chen PH, Lako A, Sung ICH, Goswami R, Kim MY, et al.detection of individual proteins was carried out by blotting with specific primary antibody against MFN2 (ab56889, AbCam, Cambridge, MA, 1:1,000), CPT1 (GTX114337, GeneTex, 1:1,000), VDAC (Abcam, 1:1,000), Phospho‐DRP1

(11) Substitution of PINK1 Gly411 modulates substrate receptivity and turnoverAutophagyJune 1, 2023Fiesel FC, Fričová D, Hayes CS, Coban MA, Hudec R, Bredenberg JM, Broadway BJ, Markham BN, Yan T, Boneski PK, et al.Bank, H4B4-c; 1:1,000), chicken anti-MAP2 (IF; Abcam, ab5392; 1:2,000), mouse anti-MFN2 (IB; Abcam, ab56889; 1:5,000), rabbit anti-PINK1 (IB; Cell Signaling Technology, 6946; 1:2,500), mouse anti-PINK1 (IB; Biolegend,

(12) High-fat diet causes mitochondrial damage and downregulation of mitofusin-2 and optic atrophy-1 in multiple organsJournal of Clinical Biochemistry and NutritionMay 25, 2023Peng Zheng, Wenjing Ma, Yilu Gu, Hengfang Wu, Zhiping Bian, Nannan Liu, Di Yang, Xiangjian Chenin muscle tissue; Abcam, Cambridge, UK), a key protein for mitochondrial fusion mitofusin-2 (MFN2, ab56889 used for kidney tissue, 1:200; Abcam; 12186-1-AP used for heart and skeletal muscle tissue, 1:400; Proteintech,

(13) Kidney-Related Function of Mitochondrial Protein MitoregulinInternational Journal of Molecular SciencesMay 22, 2023Olga A. Averina, Oleg A. Permyakov, Mariia A. Emelianova, Ekaterina A. Guseva, Olga O. Grigoryeva, Maxim L. Lovat, Anna E. Egorova, Andrei V. Grinchenko, Vadim V. Kumeiko, Maria V. Marey, et al.The following primary antibodies were used: anti-OPA1 (ab42364, Abcam, Waltham, MA, USA), anti-MFN2 (ab56889, Abcam, Waltham, MA, USA), anti-CYB5R3 (sc-398043), anti-VDAC1 (ab15895, Abcam, Waltham, MA, USA). The

(14) Obesity impairs cardiolipin-dependent mitophagy and therapeutic intercellular mitochondrial transfer ability of mesenchymal stem cellsCell death & diseaseMay 13, 2023Sagar S, Faizan MI, Chaudhary N, Singh V, Singh P, Gheware A, Sharma K, Azmi I, Singh VP, Kharya G, et al.Antibodies,Primary Antibodies,Primary Antibodies S. No.,Name,Company,Catalogue No. 1,Anti-Mitofusin 2,Abcam,ab56889 2,Recombinant Anti-DRP1,Abcam,ab184247 3,Anti-PGC1 alpha,Abcam,ab54481 4,Anti-MIRO1,Abcam,ab83779 5,Anti-LC3B,Abcam,ab48394 6,Anti-TOMM20,Abcam,ab56783 7,Anti-LAMP1,Abcam,ab25245 8,Recombinant

(15) Mitofusin 2 Sustains the Axonal Mitochondrial Network to Support Presynaptic Ca2+ Homeostasis and the Synaptic Vesicle Cycle in Rat Hippocampal AxonsThe Journal of NeuroscienceMay 10, 2023Jason D. Vevea, Edwin R. Chapmanhttp://n2t.net/addgene:105009 ; RRID:Addgene_105009, Antibody,anti-MFN2 (mouse monoclonal),Abcam; Abnova,"Abcam Cat# ab56889, RRID:AB_2142629; Abnova Cat# H00009927-M01, RRID:AB_714775",IB (1:1000) Antibody,anti-SYT1 (mouse

(16) Sp1 promotes tumour progression by remodelling the mitochondrial network in cervical cancerJournal of translational medicineMay 6, 2023Xu X, Wang X, Chen Q, Zheng A, Li D, Meng Z, Li X, Cai H, Li W, Huang S, et al.antibodies were as follows: Sp1 (1:2000, ab124804, Abcam), MFN 1 (1:10,000, ab129154, Abcam), MFN2 (1:1500, ab56889, Abcam), DRP1 (1:2000, ab184247, Abcam), OPA1 (1:3000, 80,471, Cell Signaling Technology), Bcl2 (1:1000,

(17) Ginsenoside compound K protects against cerebral ischemia/reperfusion injury via Mul1/Mfn2-mediated mitochondrial dynamics and bioenergyJournal of ginseng researchMay 1, 2023Huang Q, Li J, Chen J, Zhang Z, Xu P, Qi H, Chen Z, Liu J, Lu J, Shi M, et al.(ab143424), antimycin A (ab141904), and antibodies against total OXPHOS (ab110413), Mfn1 (ab104274), Mfn2 (ab56889), DRP1 (ab56788), ubiquitin (Abcam, ab140601), FIS1 (ab71498), and OPA1 (ab90857) were obtained from

(18) Mitochondrial Health Index Correlates with Plasma Circulating Cell-Free Mitochondrial DNA in Bipolar DisorderResearch SquareApril 27, 2023Giselli Scaini, Rafaela Cordeiro, Camila Carvalho Lima, Gabriel Fries, Giovana Zunta-Soares, Jair C. Soares, Joao de Quevedodry milk. The membranes were incubated overnight at 4°C with primary antibodies against Mfn-2 (Abcam, ab56889), Opa-1 (Invitrogen, MA5-16149), Fis-1 (Abcam, ab156865), Parkin (Santa Cruz Biotechnology, Inc., sc32282),

(19) Molecular phenotypes of mitochondrial dysfunction in clinically non-manifesting heterozygous PRKN variant carriersnpj Parkinson's DiseaseApril 18, 2023Maria Paulina Castelo Rueda, Alessandra Zanon, Valentina Gilmozzi, Alexandros A. Lavdas, Athina Raftopoulou, Sylvie Delcambre, Fabiola Del Greco M, Christine Klein, Anne Grünewald, Peter P. Pramstaller, et al.were transferred onto a PVDF membrane (BioRad) and probed with antibodies raised against MFN2 (Abcam, ab56889), TOM70 (Abcam, ab135602), SOD2 (Cell Signaling, 13141 S), Parkin (Abcam, 77924), and GAPDH (Millipore,

(20) Widespread RNA hypoediting in schizophrenia and its relevance to mitochondrial functionScience AdvancesApril 7, 2023Mudra Choudhury, Ting Fu, Kofi Amoah, Hyun-Ik Jun, Tracey W. Chan, Sungwoo Park, David W. Walker, Jae Hoon Bahn, Xinshu Xiao(ATP5a) (Abcam, ab14748), Cyt C (Santa Cruz Biotechnology, sc-13156), MFN1 (Abcam, ab57602), MFN2 (Abcam, ab56889), and β-actin (Santa Cruz Biotechnology, sc-47778). The antibodies were detected using horseradish peroxidase–conjugated

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11/21/2014Staining for Mfn 2 in neural stem cells Vasundhra BahlAnti Mfn-2 was used to detect effect of environmental toxicants on mitochondrial fusion in stem cells. This antibody worked well and the labeling obtained was clean after allowing tritox X ... Read Review

Anti-Mitofusin 2 antibody [6A8] from Abcam

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Anti-Mitofusin 2 antibody [6A8] from Abcam

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