Description
Product Characteristics: COL15A1(Collagen alpha-1(XV) is a structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle. Endostatin potently inhibits angiogenesis. COL15A1 is expressed predominantly in internal organs such as adrenal gland, pancreas and kidney. It belongs to the fibril-associated collagens with interrupted helices (FACIT) family. It contains 1 TSP N-terminal (TSPN) domain.
Target Information: This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration. [provided by RefSeq, Jul 2008]