Fig 1: Representative western blotting of intercalated disc proteins and β-tubulin in the right ventricular myocardium from patients with AC and healthy controls. (A) Western blotting of myocardial intercalated disc proteins in the controls, and AC patients with and without DSG2 variation, along with the quantification of the protein expression; (B) western blotting of myocardial intercalated disc proteins in the controls, and AC patients with and without PKP2 variation, along with the quantification of the protein expression. DSG2, desmoglein 2; JUP, junction plakoglobin; Cx43, connexin 43; PKP2, plakophilin 2.
Fig 2: Sequencing results of the three desmosomal gene mutations identified. PKP2, plakophilin 2.
Fig 3: Immunohistochemistry of the right ventricular myocardium from desmosomal gene variation carriers. (A) Immunostaining of intercalated disc protein in patients with DSG2 L797Q (magnification, ×400); (B) immunostaining of intercalated disc protein in patients with PKP2 S249T and G808fsX30 (magnification, ×400). Scale bar, 50 µm. DSG2, desmoglein 2; N-Cad, N-cadherin; JUP, junction plakoglobin; Cx43, connexin 43; PKP2, plakophilin 2.
Supplier Page from Abcam for Anti-Plakophilin 2/PKP2 antibody [8H6]