Fig 1: Gene and protein expression in primary tumours and matched bone metastases from ER+ and ER- PDX. a Fold change in gene expression from RNA isolated from human bone metastatic deposits compared with the corresponding primary PDXs. Data shown are mean ± SEM for 2 independent repeats of 3 replicates. **p < 0.001, ***p < 0.0001. b Photomicrographs of primary tumours and metastases in human bone implants following immunohistochemical detection of S100A4, Fibronectin, Ras IL-1B, IL1R1 and ? Catenin. All data shown are from ER+ PR+ HER2- BB2RC08 and ER- PR- HER2- BB2RC37 PDXs