Anti-LDL Receptor antibody [EP1553Y] ab52818 from Abcam

Product Specs
ItemAnti-LDL Receptor antibody [EP1553Y]
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab52818
Antibody TypePrimary
CloneEP1553Y
IsotypeIgG
ClonalityMonoclonal
HostRabbit
Quantity10 UL, 40 UL, 100 UL
ApplicationsImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot
Conjugate/TagUnconjugated
Gene NameLDLR
ReactivityHuman, Mouse
TargetLDL Receptor

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Legacy perfluoro-alkyl substances impair LDL-cholesterol uptake independently from PCSK9-functionToxicology ReportsDecember 1, 2023Iva Sabovic, Maria Giovanna Lupo, Ilaria Rossi, Federica Pedrucci, Andrea Di Nisio, Stefano Dall’Acqua, Nicola Ferri, Alberto Ferlin, Carlo Foresta, Luca De ToniCayman Chemical (Ann Arbor, Michigan, USA). Anti LDL-Receptor rabbit polyclonal (Clone: EP1553Y; cat# ab52818) was purchased from Abcam (Cambridge, UK). Sphingosine (cat# 860490 P) and protease inhibitor cocktail

(2) The Lin28b/Wnt5a axis drives pancreas cancer through crosstalk between cancer associated fibroblasts and tumor epitheliumNature CommunicationsOctober 28, 2023Zhaoqi Shu, Minghe Fan, Bo Tu, Zhiheng Tang, Haojie Wang, Haimeng Li, Hengchao Li, Meng Yuan, Jingru Bai, Sihan Huo, et al.anti-Pcsk9 (Abcam, #ab185194, 1:1000), anti-PGRN (Abcam, #ab187070, 1:1000), and anti-‍Ldlr (Abcam, #ab52818, 1:500) for WB; anti-Ki67 (Abcam, #ab16667, 0.03 μg/ml), anti-α-SMA (Gene Tech, #GM085129, 1:100), anti-CK19

(3) Autophagy-urea cycle pathway is essential for the statin-mediated nitric oxide bioavailability in endothelial cellsJournal of Food and Drug AnalysisAugust 31, 2023Wen-Hua Chen, Bei-Chia Guo, Chia-Hui Chen, Man-Chen Hsu, Chih-Hsien Wang, Tzong-Shyuan LeeABclonal Science (Woburn, MA, USA). Rabbit antibodies for autophagy related 7 (ATG7, ab133528) and LDLR (ab52818) were from Abcam (Cambridge, MA, UK). Mouse antibody for α-tubulin was purchased from Croyez (Taipei,

(4) Down-Regulation of ABCA7 in Human Microglia, Astrocyte and THP-1 Cell Lines by Cholesterol Depletion, IL-1β and TNFα, or PMACellsAugust 25, 2023Wiener JP, Desire S, Garliyev V, Lyssenko Iii N, Praticò D, Lyssenko NN.NB400-105, Novus Biologicals, Centennial, CO, USA), rabbit monoclonal anti-LDLR (EP1553Y) (1:500 dilution; ab52818, Abcam, Cambridge, United Kingdom), rabbit monoclonal anti-LDLR (SJ0197) (1:1000 dilution; MA5-32075,

(5) Anlotinib affects systemic lipid metabolism and induces lipid accumulation in human lung cancer cellsLipids in Health and DiseaseAugust 23, 2023Zhongling Zhu, Shan Xu, Jing Ren, Teng Jiang, Cai Zhang, Zhao YanUSA). Antibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) (ab242315), LDLR (ab52818) were purchased from Abcam (Cambridge, MA, USA). Antibodies against sterol response element binding

(6) Exosomal circ_0008285 in follicle fluid regulates the lipid metabolism through the miR-4644/ LDLR axis in polycystic ovary syndromeJournal of Ovarian ResearchJune 15, 2023Li Yu, Chen Wang, Doudou Zhang, Miao Liu, Te Liu, Baishen Pan, Qi Che, Suying Liu, Beili Wang, Xi Dong, et al.(13403S, 1:1000, CTS), TSG101 (ab125011, 1:1000, Abcam), Calnexin (ab125011, 1:1000, Abcam), LDLR (ab52818, 1:1000, Abcam), and beta-Tubulin (T0023, 1:1000, Affinity Biosciences), and then incubated with the

(7) Improved extracellular vesicle-based mRNA delivery for familial hypercholesterolemia treatmentTheranosticsJune 12, 2023Zheng Yang, Panpan Ji, Zhelong Li, Rongxin Zhang, Mengying Wei, Yang Yang, Lijun Yuan, Yan Han, Guodong Yanganti-CD9 (ab92726, Abcam), anti-TSG101 (ab83, Abcam), anti-MCP (ABE76, Merck Millipore), and anti-LDLR (ab52818, Abcam) overnight at 4°C. After washing in TBST, the membranes were incubated with secondary antibodies

(8) TNFα Activates the Liver X Receptor Signaling Pathway and Promotes Cholesterol Efflux from Human Brain Pericytes Independently of ABCA1International journal of molecular sciencesMarch 22, 2023Dib S, Loiola RA, Sevin E, Saint-Pol J, Shimizu F, Kanda T, Pahnke J, Gosselet F.(BCRP),72,Ab207732,Abcam,non-heated/reduced,1:1000 ABCG4,100,PA5-34855,Invitrogen,heated/reduced,1:1000 SR-BI,80,ab52629,Abcam,heated/reduced,1:1000 HMGCR,100,Mab90619,Sigma,non-heated/reduced,1:1000 LRP1,80,sc57351,Santa Cruz,heated/reduced,1:500 LDLR,140,ab52818,Abcam,heated/reduced,1:1000 APOE,34,ab1906,Abcam,heated/reduced,1:1000 COX2,70,NBD100-689SS,Novus,heated/reduced,1:1000 NLRP3,118,ab263899,Abcam,heated/reduced,1:1000 VCAM1,90–100,ab134047,Abcam,heated/reduced,1:1000 IL-6,22–28,NBD600-1131SS,Novus,heated/reduced,1:1000 PhosphoNF-κB,66–75,Mab72261,R&D,heated/reduced,1:1000 NF-κB,66–75,ab32536,Abcam,heated/reduced,1:1000 ACTIN,42,A5441,Sigma,heated/reduced,"1:10,000" Western blot

(9) Di-(2-ethylhexyl) Phthalate Limits the Lipid-Lowering Effects of Simvastatin by Promoting Protein Degradation of Low-Density Lipoprotein Receptor: Role of PPARγ-PCSK9 and LXRα-IDOL Signaling PathwaysAntioxidants (Basel)February 14, 2023Bei-Chia Guo, Ko-Lin Kuo, Jenq-Wen Huang, Chia-Hui Chen, Der-Cherng Tarng, Tzong-Shyuan LeeSanta Cruz Biotechnology (Santa Cruz, CA, USA). Rabbit and mouse antibodies for low-density lipoprotein receptor (LDLR, ab52818), PCSK9 (ab31762), PPARγ (ab209350), IDOL (MYLIP, ab74562), and LXRα (ab41902) were obtained from Abcam

(10) PCSK9 deficiency alters brain lipid composition without affecting brain development and functionFrontiers in Molecular NeuroscienceJanuary 17, 2023Angela Pärn, Ditte Olsen, Jürgen Tuvikene, Mathias Kaas, Ekaterina Borisova, Mesut Bilgin, Mie Elhauge, Joachim Vilstrup, Peder Madsen, Mateusz C. Ambrozkiewicz, et al.Healthcare) with a Fuji film LAS3000 system. The following antibodies were used: Rabbit anti-LDLR (Abcam ab52818, 1:600), Mouse anti-beta actin (Sigma A5441, 1:5000). Secondary HRP-linked antibodies were used in 1:2000

(11) Adaptive activation of EFNB2/EPHB4 axis promotes post-metastatic growth of colorectal cancer liver metastases by LDLR-mediated cholesterol uptakeOncogeneJanuary 1, 2023Xu C, Gu L, Kuerbanjiang M, Jiang C, Hu L, Liu Y, Xue H, Li J, Zhang Z, Xu Q.previously described [39]. EFNB2 (ab69858, Abcam, Cambridge, UK), EPHB4 (ab150545, ab98933, Abcam), LDLR (ab52818, Abcam), β-catenin (ab32572, Abcam), VLDLR (ab203271, Abcam), SCARB1(ab52629, Abcam), STAT3(ab68153,

(12) Atorvastatin improves cisplatin sensitivity through modulation of cholesteryl ester homeostasis in breast cancer cellsDiscover OncologyDecember 8, 2022Diandra Zipinotti dos Santos, Isabella dos Santos Guimaraes, Mariam F. Hakeem-Sanni, Blake J. Cochran, Kerry-Anne Rye, Thomas Grewal, Andrew J. Hoy, Leticia B. A. RangelAbcam), ACAT-1 (mouse anti-ACAT-1; sc-69,836; 1:1,000; Santa Cruz Biotechnology), LDLR (rabbit anti‐LDLR; ab52818, 1:500; Abcam), and 14-3-3 (rabbit anti-14-3-3, #8312S, 1:1000, Cell Signaling Technology). Membranes

(13) Black TiO2 nanoprobe-mediated mild phototherapy reduces intracellular lipid levels in atherosclerotic foam cells via cholesterol regulation pathways instead of apoptosisBioactive MaterialsNovember 1, 2022Ting Dai, Wenming He, Shuangshuang Tu, Jinru Han, Bo Yuan, Chenyang Yao, Wenzhi Ren, Aiguo WuShanghai, China). Antibody sources were as follows: anti-LDL Receptor rabbit antibody (1:500 dilution, ab52818), anti-SREBP2 rabbit antibody (1:500 dilution, ab30682), anti-beta Actin antibody (1:1000 dilution,

(14) A multienzyme S-nitrosylation cascade regulates cholesterol homeostasisCell reportsOctober 25, 2022Stomberski CT, Venetos NM, Zhou HL, Qian Z, Collison BR, Field SJ, Premont RT, Stamler JS.RRID:AB_118799 Rabbit polyclonal GAPDH,Proteintech,10494-1-AP RRID:AB_2263076 Rabbit monoclonal LDLR,Abcam,ab52818 RRID:AB_881213 Goat polyclonal mouse PCSK9,R&D Systems,AF3985 RRID:AB_2044717 Rabbit monoclonal human

(15) Hepatic inactivation of murine Surf4 results in marked reduction in plasma cholesteroleLifeOctober 4, 2022Tang VT, McCormick J, Xu B, Wang Y, Fang H, Wang X, Siemieniak D, Khoriaty R, Emmer BT, Chen XW, et al.R-15771,WB(1:1000) Antibody,Anti-PCSK9 – rabbit polyclonal,Abcam,ab31762,WB (1:1000) Antibody,Anti-LDLR – rabbit monoclonal,Abcam,ab52818,WB (1:1000) Antibody,Anti-HSP90 – rabbit monoclonal,Cell Signaling Technology,4877,WB (1:1000) Antibody,Anti-SURF4

(16) Brain Endothelial Cells in Contrary to the Aortic Do Not Transport but Degrade Low-Density Lipoproteins via Both LDLR and ALK1CellsSeptember 28, 2022Kakava S, Schlumpf E, Panteloglou G, Tellenbach F, von Eckardstein A, Robert J.(PBST), membranes were incubated with SR-BI (Novus NB400-134, RRID:AB_10003304, 1:1000), LDLR (Abcam ab52818, RRID:AB_881213, 1:500–1:1000), ALK1 (Abcam ab108207, RRID:AB_10858289, 1:1000), CAV1 (Abcam ab2910,

(17) LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxinCommunications BiologySeptember 5, 2022Yao Zhou, Danyang Li, Diyin Li, Aizhong Chen, Liuqing He, Jianhua Luo, Liang Taorabbit polyclonal IgG against β-Actin (ab227387, 1:5000, Abcam), rabbit monoclonal IgG against LDLR (ab52818 for western blot, 1:500; ab30532 for immunofluorescence, 1:200; Abcam), rabbit monoclonal IgG against

(18) Neuronal ApoE Regulates the Cell-to-Cell Transmission of α-SynucleinInternational Journal of Molecular SciencesJuly 27, 2022Seo-Jun Kang, Soo-Jeong Kim, Hye Rin Noh, Beom Jin Kim, Jae-Bong Kim, Uram Jin, Sun Ah Park, Sang Myun ParkLRP-1 (#64099S) was supplied by Cell Signaling Technology (Danvers, MA, USA). Antibodies against LDLR (#ab52818), tubulin (#ab6046), and pSer129 α-syn (#ab51253 for Western blotting) were purchased from Abcam (Cambridge,

(19) Proprotein convertase PCSK9 affects expression of key surface proteins in human pancreatic beta cells via intracellular and extracellular regulatory circuitsThe Journal of biological chemistryJuly 1, 2022Saitoski K, Ryaboshapkina M, Hamza GM, Jarnuczak AF, Berthault C, Carlotti F, Armanet M, Sengupta K, Underwood CR, Andersson S, et al.Tris-buffered saline 0.1% Tween with 0.5% bovine serum albumin (BSA); LDLR (1/1000 dilution; catalog no.: ab52818; Abcam), VLDLR (1/1000 dilution; catalog no.: ab75591; Abcam), alpha-tubulin (1/2000 dilution; catalog

(20) Effects of statins on the inducible degrader of low-density lipoprotein receptor in familial hypercholesterolemiaEndocrine ConnectionsJune 15, 2022Melody Lok-Yi Chan, Sammy Wing-Ming Shiu, Ching-Lung Cheung, Anskar Yu-Hung Leung, Kathryn Choon-Beng Tanpowdered skimmed milk with either rabbit anti-human MYLIP/IDOL (ab74562, Abcam), rabbit anti-human LDLR (ab52818, Abcam), rabbit anti-human LXR-α (TA325122, OriGene, Rockville, MD, USA) or mouse anti-human PCSK9 (ab84041,

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8/30/2016Review of Abcam Anti-LDL Receptor antibody [EP1553Y] (ab52818) Nneka MbahUsed this antibody for a western blot to determine LDL Receptor protein levels in U251 glioma cells. Cells were serum starved overnight, incubated with cycloheximide (10ug/ml) to block synthesis of ... Read Review

Anti-LDL Receptor antibody [EP1553Y] from Abcam

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Anti-LDL Receptor antibody [EP1553Y] from Abcam

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