Anti-Chk2 antibody ab47433 from Abcam

Product Specs
ItemAnti-Chk2 antibody
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab47433
Antibody TypePrimary
HostRabbit
ApplicationsImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot
Quantity100 UG
ClonalityPolyclonal
IsotypeIgG
Conjugate/TagUnconjugated
FormatAffinity purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen
Concentration1 mg/ml
Research AreaEpigenetics
Gene NameCHEK2
ReactivityHuman
TargetChk2

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) ADAR1 links R-loop homeostasis to ATR activation in replication stress responseNucleic acids researchNovember 27, 2023Zhang B, Li Y, Zhang J, Wang Y, Liang C, Lu T, Zhang C, Liu L, Qin Y, He J, et al.(2737T, for IF) from Cell Signaling Technology; and FLAG (F3165, IB, IF and IP) from Sigma-Aldrich; CHK2 (ab47433, for IB) and RPA2 (ab2175, for IF) from Abcam; TOPBP1 (A300-111A, for IB and IP), RAD9 (A300-890A, for

(2) ATM Pathway Is Essential for HPV–Positive Human Cervical Cancer-Derived Cell Lines Viability and ProliferationPathogensJune 1, 2022Walason Abjaude, Bruna Prati, Veridiana Munford, Aline Montenegro, Vanesca Lino, Suellen Herbster, Tatiana Rabachini, Lara Termini, Carlos Frederico Martins Menck, Enrique Boccardononfat milk, probed with primary antibodies against ATM (Ab78), ATM (phospho S1981) (Ab81292), CHK2 (Ab47433), γH2AX (ab22551) from Abcam (Cambridge, MA, UK); and tubulin (sc-25259) from Santa Cruz Biotechnology

(3) Chemotherapy of HER2- and MDM2-Enriched Breast Cancer Subtypes Induces Homologous Recombination DNA Repair and ChemoresistanceCancersSeptember 7, 2021Herok M, Wawrzynow B, Maluszek MJ, Olszewski MB, Zylicz A, Zylicz M.Gilbertsville, PA, USA, 1:500), pBRCA1 (Ser1524) (#9009, Cell Signaling, Danvers, MA, USA, 1:250), Chk2 (ab47433, Abcam, Cambridge, UK, 1:500), and pChk2 (Thr68) (#2197, Cell Signaling, Danvers, MA, USA, 1:250). Secondary

(4) A novel M phase blocker, DCZ3301 enhances the sensitivity of bortezomib in resistant multiple myeloma through DNA damage and mitotic catastropheJournal of Experimental & Clinical Cancer ResearchDecember 1, 2020Liangning Hu et al.1:1000), phospho-CHK1 (#ab47318,1:1000), CHK1 (#ab40866, 1:1000), phospho-CHK2 (#ab85742, 1:1000), CHK2 (#ab47433, 1:1000), phospho-DNA PKCs (#ab124918, 1:1000) were from Abcam (Abcam, Cambridge, UK). BRCA1 (#sc135732,

(5) FadA promotes DNA damage and progression of Fusobacterium nucleatum-induced colorectal cancer through up-regulation of chk2Journal of Experimental & Clinical Cancer ResearchDecember 1, 2020Pin Guo et al.m0879, Dako, Carpinteria, CA, USA), β-catenin (1:2000, ab6302, Abcam, Cambridge, UK), and chk2 (1:200, ab47433, Abcam, Cambridge, UK). The sections were observed under a fluorescence microscope (Zeiss, Thornwood,

(6) Ginsenoside Rh2 pretreatment and withdrawal reactivated the pentose phosphate pathway to ameliorate intracellular redox disturbance and promoted intratumoral penetration of adriamycinRedox BiologyMay 1, 2020Jiali Liu, Qingyun Cai, Wenjie Wang, Meng Lu, Jianming Liu, Fang Zhou, Minjie Sun, Guangji Wang, Jingwei Zhangused to detect protein expression: anti-G6PD (1:1000, Abcam, Cat#AB993), anti-Chk2 (1:1000, Abcam, Cat#AB47433), anti-p53 (1:1000, Abcam, Cat#AB26), and anti-p65 (1:1000, Biogot Technology, Cat#BS1254). Before detection,

(7) Intrinsically Disordered SRC-3/AIB1 Protein Undergoes Homeostatic Nuclear Extrusion by Nuclear Budding While Ectopic Expression Induces NucleophagyCellsOctober 19, 2019Cabrita MA, Renart LI, Lau R, Pratt MAC.TX), anti-lamin B1(ab16048), rabbit-anti-cyclin E1(ab7959), rabbit anti-vinculin(ab129002), anti-Chk2(ab47433) (Abcam, Cambridge, MA), anti-PML(#PA5-80909), anti-SUMO-1(#PA5-11312) and anti-RanGAP1(#33-0800) (ThermoFisher Scientific

(8) An overactive neddylation pathway serves as a therapeutic target and MLN4924 enhances the anticancer activity of cisplatin in pancreatic cancerOncology LettersJuly 9, 2019Yu Zeng, Yong‑Shuang Iv, Qi‑Hua Pan, Yi‑Guo Zhou, He Li9664; Cell Signaling Technology, Inc.), CHK1 (1:1,000; cat. no. ab40866; Abcam), CHK2 (1:1,000; cat. no. ab47433; Abcam), H2AX (1:1,000; cat. no. ab11175; Abcam), Iκ Bα (1:1,000; cat. no. ab32518; Abcam) and cullin

(9) Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cellsJournal of experimental & clinical cancer research : CRMay 3, 2019Liu X, Zhao P, Wang X, Wang L, Zhu Y, Song Y, Gao W.phospho-mTOR (cat. no. ab109268), p38 (cat. no. ab170099), phospho-p38 (cat. no. ab195049), Chk2 (cat. no. ab47433), phospho-Chk2 (cat. no. ab59408), Cdc25C (cat. no. ab226958), phospho-Cdc25C (cat. no. ab47322) and

(10) The novel long non‑coding RNA PRNCR1‑2 is involved in breast cancer cell proliferation, migration, invasion and cell cycle progressionMolecular Medicine ReportsDecember 24, 2018Danmei Pang, Qian Hu, Xiaoshan Lan, Yingxin Lin, Haibo Duan, Shuo Cao, Yaodong Lin, Litao Li, Feng Peng, Fengtao Panantibodies against phosphorylated (p)‑checkpoint kinase 2 p‑CHK2 (cat. no. ab59408; 1:1,000), CHK2 (cat. no. ab47433; 1:1,000), p‑protein kinase B p‑AKT (cat. no. ab38449; 1:500) and AKT (cat. no. ab179463; 1:500; all

(11) β‑catenin nuclear translocation induced by HIF‑1α overexpression leads to the radioresistance of prostate cancerInternational Journal of OncologyApril 12, 2018Yong Luo et al.(Y15, ab47594, 1:1,000), anti-Chk1 (ab47574, 1:1,000), anti-p-Chk1 (S296, ab79758, 1:500), anti-Chk2 (ab47433, 1:500), anti-p-Chk2 (T387, ab55319, 1:500), anti-Rb (ab226979, 1:1,000), anti-p-Rb (S780, ab173289,

(12) HBV infection potentiates resistance to S-phase arrest-inducing chemotherapeutics by inhibiting CHK2 pathway in diffuse large B-cell lymphomaCell Death & DiseaseFebruary 1, 2018Xinying Zhao, Xudong Guo, Libo Xing, Wenqin Yue, Haisen Yin, Miaoxia He, Jianmin Wang, Jianmin Yang, Jie ChenAbcam, Cambridge, MA, USA), anti-P-CHK2 (2197S, Cell Signaling Technology, Danvers, MA, USA), anti-CHK2 (ab47433, Abcam), anti-ATM (ab199726, Abcam), anti-P21 (ab7960, Abcam), anti-P53 (BS1913, Bioworld, Minnesota,

(13) MASTL is essential for anaphase entry of proliferating primordial germ cells and establishment of female germ cells in miceCell DiscoveryDecember 1, 2017Sanjiv Risal et al.(Abcam, ab15580), mouse p-ATM (S1981) (Santa Cruz Biotechnology, 10H11.E12, sc47739), rabbit Chk2 (Abcam, ab47433), rabbit γ-H2AX (S139) (Abcam, ab2893), mouse p53 (Abcam PAb 240, ab26), rabbit PUMA (Millipore, Billerica,

(14) Ataxia-Telangiectasia Mutated (ATM) Protein Signaling Participates in Development of Pulmonary Arterial Hypertension in RatsMedical Science MonitorSeptember 12, 2017Fan Hu, Caijun Liu, Hanmin Liu, Liang Xie, Li Yu(ab78) Phosphorylated ATM (primary) Mouse 1: 200 Abcam (ab36810) Chk2 (primary) Rabbit 1: 100 Abcam (ab47433) P53 (primary) Mouse 1: 400 Abcam (ab26) Phosphorylated P53 (primary) Rabbit 1: 100 Abcam (ab33889) P21

(15) Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers?Antioxidants & redox signalingDecember 1, 2014Abdel-Fatah TM, Perry C, Arora A, Thompson N, Doherty R, Moseley PM, Green AR, Chan SY, Ellis IO, Madhusudan S.Biologicals,Citrate pH6,1:20,Nuclear,H-score,≥60 (High) ,,,,,18 h,,, Chk2,Rabbit polyclonal anti-Chk2,Ab47433,Abcam,Citrate pH6,1:100,Nuclear,H-score,≥100 (High) ,,,,,60 min,,, pChk1,Rabbit anti-pChk1,Ab58567,Abcam,Citrate

(16) Clinicopathological Significance of ATM-Chk2 Expression in Sporadic Breast Cancers: a Comprehensive Analysis in Large CohortsNeoplasia (New York, N.Y.)November 1, 2014Tarek M A Abdel-Fatah, Arvind Arora, Nouf Alsubhi, Devika Agarwal, Paul M Moseley, Christina Perry, Rachel Doherty, Stephen Y T Chan, Andrew R Green, Emad Rakha, Graham Ball, Ian O Ellis, Srinivasan Madhusudanfurther set of slides was incubated for 60 minutes with the primary rabbit polyclonal anti-Chk2 antibody (Ab47433, Abcam, Cambridge, UK) at a dilution of 1:100. To evaluate the use of TMAs for immunophenotyping, full-face

(17) BRCA2 protein deficiency exaggerates doxorubicin-induced cardiomyocyte apoptosis and cardiac failureThe Journal of biological chemistryFebruary 24, 2012Krishna K Singh, Praphulla C Shukla, Adrian Quan, Jean-François Desjardins, Fina Lovren, Yi Pan, Vinay Garg, Sumandeep Gosal, Ankit Garg, Paul E Szmitko, Michael D Schneider, Thomas G Parker, William L Stanford, Howard Leong-Poi, Hwee Teoh, Mohammed Al-Omran, Subodh Verma

(18) ShRNA-Targeted Centromere Protein A Inhibits Hepatocellular Carcinoma GrowthPLoS ONEMarch 15, 2011Yongmei Li, Zhi Zhu, Shuhui Zhang, Danghui Yu, Hongyu Yu, Lina Liu, Xiaozhe Cao, Li Wang, Hengjun Gao, Minghua Zhuanti-Bax (sc-7480, Santa Cruz Biotech; 1∶300), anti-MDM2 (sc-965, Santa Cruz Biotech; 1∶400), anti-CHK2 (ab47433, Abcam, Cambridge, UK; 1∶500), anti-RAD51 (ab88572, Abcam, Cambridge, UK; 1∶500), and anti-cyclin G.1(sc-8016,

(19) Mechanism of genomic instability in cells infected with the high-risk human papillomavirusesPLoS pathogensApril 1, 2009Kadaja M, Isok-Paas H, Laos T, Ustav E, Ustav M.PCNA (ab18197), Mre11 (ab214), Rad50 (ab89), Ku70/80 (ab3108), ATM (ab32420), ATRIP (ab19351), Chk2 (ab47433), Chk1 (ab47488) and phospho-Chk1 (S317; ab38518) were purchased from Abcam. The Daxx (sc7152) antibody

(20) DNA damage response of A549 cells treated with particulate matter (PM 10) of urban air pollutantsCancer LettersJanuary 6, 2009Yesennia Sánchez-Pérez, Yolanda I. Chirino, Álvaro R. Osornio-Vargas, Rocío Morales-Bárcenas, Concepción Gutiérrez-Ruíz, Inés Vázquez-López, Claudia M. García-Cuellar

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Anti-Chk2 antibody from Abcam

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Anti-Chk2 antibody from Abcam

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