Fig 1: LncRNAs derived from enhancer elements are induced by fear extinction learning and correlate with proximal protein-coding gene expression in the adult prefrontal cortex(A) Schematic of the behavioral protocol used to collect ILPFC tissue after fear extinction training.(B) Genomic distribution of ATAC peaks in Arc+ neurons that have been activated by fear extinction learning.(C) The Venn diagram highlights 434 proximal lncRNAs overlapping with lncRNA capture-seq, Arc+ EXT ATAC-seq, as well as H3K27ac-, CBP-, and H3K4me1-enriched genomic regions.(D) Heatmap of eRNA-associated mRNA expression in quiescent (ARC-EXT) versus activated (ARC+ EXT) neurons (n = 3 biological replicates for ARC- EXT; n = 4 biological replicates ARC+ EXT; red, decreased expression; blue, increase expression).(E) Gene ontology (GO) analysis for proximal protein-coding genes located <10 kb downstream of the 434 eRNA loci. The top 30 significantly enriched GO terms are shown in the dot plot.