Fig 1: The ETS exposure will accelerate the aging and harm the heartA few autophagies that happen in healthy cardiomyocytes can help in removing the damaged organelles and maintain the physiological function of cells. Additionally, resveratrol can enhance autophagy during the aging process, but it can also provide an additional enhancement effect on IGF1R cardiac survival pathway in hearts. The autophagy induced by ETS exposure is entirely alien to resveratrol. The ETS exposure will increase the IGF2R more than the IGF1R signaling pathway, and further reduce the expression and activities of SIRT-. This proved that the ETS did not seem to affect the appearance; in fact, it could have accelerated the aging process and harmed the heart.
Fig 2: IGF2R signaling pathway analysisA. IGF2R and ANP protein levels were increased and HSF-1 protein levels were reduced after 6 weeks of ETS exposure in C57BL mice hearts. B. The quantification of protein expression in C57BL mice hearts (*p < 0.05 compared with control group).
Supplier Page from Abcam for Anti-M6PR (cation independent) (phospho S2409) antibody