Anti-RANKL antibody [12A668] - BSA and Azide free ab45039 from Abcam

Product Specs
ItemAnti-RANKL antibody [12A668] - BSA and Azide free
CompanyAbcam
Price Pricing Info Supplier Page View Company Product Page
Catalog Numberab45039
Antibody TypePrimary
Quantity100 UG
ClonalityMonoclonal
ApplicationsImmunocytochemistry/ Immunofluorescence, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot
HostMouse, Nude mouse
Clone12A668
IsotypeIgG1
Conjugate/TagUnconjugated
Concentration0.5 mg/ml
Gene NameTNFSF11
ReactivityHuman
TargetRANKL

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Abcam

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Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

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Website: http://www.abcam.com

(1) Ambient PM2.5 Exposure and Bone Homeostasis: Analysis of UK Biobank Data and Experimental Studies in Mice and in VitroEnvironmental Health PerspectivesOctober 4, 2023Qinwen Ge, Sijia Yang, Yu Qian, Jiali Chen, Wenhua Yuan, Sanduo Li, Pinger Wang, Ran Li, Lu Zhang, Guobo Chen, et al.#ab13420; 1:300), anti-cathepsin K (Ctsk) antibody (Abcam; #ab188604; 1:200), anti-RANKL antibody (Abcam; #ab45039; 1:300), anti-interleukin-1β (IL-1β) antibody (Abcam; #ab9722; 1:300), and anti-TNF-α antibody (Arigo;

(2) Bisphosphonate conjugation enhances the bone-specificity of NELL-1-based systemic therapy for spaceflight-induced bone loss in micenpj MicrogravitySeptember 18, 2023Pin Ha, Jin Hee Kwak, Yulong Zhang, Jiayu Shi, Luan Tran, Timothy Pan Liu, Hsin-Chuan Pan, Samantha Lee, Jong Kil Kim, Eric Chen, et al.immunolabeled with the following antibodies: osteocalcin (Santa Cruz, Cat# sc-365797) and RANKL (Abcam, Cat# ab45039). Photomicrographs were acquired using Olympus BX 51 and IX 71 microscopes equipped with the Cell Sense

(3) Osteoclast differentiation and dynamic mRNA expression during mice embryonic palatal bone developmentScientific ReportsSeptember 13, 2023Yongzhen Lai, Yan Guo, Caiyu Liao, Chuanqing Mao, Jing Liu, Chengyan Ren, Wen Yang, Lin Luo, Weihui ChenAbcam), anti-F4/80 (1:200, ab300421, Abcam), anti-CSF1R (1:200, ab254357, Abcam), and anti-RANKL (1:200, ab45039, Abcam). Anti-CD31 (1:300, ab28364, Abcam) and goat anti-rabbit IgG H&L (1:200, ab150080, Abcam) were

(4) Radiation Induces Bone Microenvironment Disruption by Activating the STING-TBK1 PathwayMedicina (Kaunas, Lithuania)July 16, 2023Wang Y, Ren L, Xu L, Wang J, Zhai J, Zhu G.anti-P-TBK1 (cat. no. 5483; Cell Signaling Technology, Inc., Danvers, MA, USA; 1:1000), anti-RANKL (cat. no. ab45039; Abcam; 1:1000), anti-osteoprotegerin (OPG; cat. no. ab183910; Abcam; 1:1000), anti-sclerostin (SOST;

(5) SOST gene suppression stimulates osteocyte Wnt/β-catenin signaling to prevent bone resorption and attenuates particle-induced osteolysisJournal of molecular medicine (Berlin, Germany)May 1, 2023Jiao Z, Chai H, Wang S, Sun C, Huang Q, Xu W.β-catenin (Proteintech, ab66379, 1:200 dilution), OPG (Abcam, ab183910, 1:500 dilution), and RANKL (Abcam, ab45039, 1:200 dilution). Furthermore, osteocytes were labeled with sclerostin, OPG, and RANKL, while osteoclasts

(6) Modelling stromal compartments to recapitulate the ameloblastoma tumour microenvironmentMatrix Biol PlusDecember 1, 2022Bakkalci D, Zubir AZA, Khurram SA, Pape J, Heikinheimo K, Fedele S, Cheema U.serum albumin (BSA) (Sigma-Aldrich, Dorset, UK) at room temperature. BSA diluted antibodies anti-RANKL (ab45039, Abcam, Cambridge, UK) or anti-osteonectin (SPARC) (ab225716) or anti-pan cytokeratin (GTX29377, GeneTex,

(7) Mechanical force regulates root resorption in rats through RANKL and OPGBMC oral healthJuly 16, 2022Zhou J, Guo L, Yang Y, Liu Y, Zhang C.manufacturer's protocols. Tissue sections were stained overnight at 4 °C with an anti-RANKL antibody (1:100; ab45039, Abcam, Cambridge, UK) or an anti-OPG antibody (1:200; ab9986, Abcam, Cambridge, UK), and after rinsing

(8) Melatonin inhibits osteoclastogenesis via RANKL/OPG suppression mediated by Rev-Erbα in osteoblastsJournal of cellular and molecular medicineJuly 1, 2022Tian Y, Ming J.subfamily 1 group D member 1 (NR1D1/Rev‐Erbα; cat. no. ab174309, 1:5000; Abcam), anti‐RANKL (cat. no. ab45039, 1:500; Abcam), anti‐OPG (cat. no. ab203061, 1:300; Abcam), and anti‐GAPDH (cat. no. 10494‐1‐AP, 1:10,000;

(9) N-Butanol Extract of Modified You-Gui-Yin Attenuates Osteoclastogenesis and Ameliorates Osteoporosis by Inhibiting RANKL-Mediated NF-κB SignalingFront Endocrinol (Lausanne)June 24, 2022Qinghe Zeng et al.Novusbio, NB300-620, 1:300), and Receptor activator nuclear factor-κB (NF-κB) ligand (RANKL, Abcam, Ab45039, 1:500) overnight at 4°C, respectively. The next day, these sections were treated with a homologous

(10) A neomorphic variant in SP7 alters sequence specificity and causes a high-turnover bone disorderNature communicationsFebruary 4, 2022Lui JC, Raimann A, Hojo H, Dong L, Roschger P, Kikani B, Wintergerst U, Fratzl-Zelman N, Jee YH, Haeusler G, et al.anti-myc tag (TA150121, Origene), anti-HA (ab18181, Abcam), anti-Col1a1 (ab34710, Abcam), anti-Rankl (ab45039, Abcam), or anti-Gapdh (ab9485, Abcam) antibodies. All uncropped images were provided in the Supplementary

(11) RANKL neutralisation prevents osteoclast activation in a human in vitro ameloblastoma-bone modelJournal of tissue engineeringJanuary 1, 2022Pape J, Bakkalci D, Hosni RA, Simpson BS, Heikinheimo K, Fedele S, Cheema U.1 h (both Sigma-Aldrich, Dorset, UK). 1° (1:200) antibody incubation overnight at 4°C using RANKL (ab45039) or SPARC antibody (ab225716). 2° antibody (1:1000) was incubated for 2.5 h at room temperature with

(12) Targeted blockade of immune mechanisms inhibit B precursor acute lymphoblastic leukemia cell invasion of the central nervous systemCell Reports MedicineDecember 21, 2021Sujeetha A. Rajakumar, Ildiko Grandal, Mark D. Minden, Johann K. Hitzler, Cynthia J. Guidos, Jayne S. DanskaBCR-ABL1 PDX mice were stained with anti-mouse or human RANKL (clone: 12A668; 1:25 dilution; Abcam, ab45039) primary antibody and processed as previously described for human CD19 staining.17 Dewaxed and rehydrated

(13) Bioengineering the ameloblastoma tumour to study its effect on bone nodule formationScientific reportsDecember 16, 2021Bakkalci D, Jay A, Rezaei A, Howard CA, Haugen HJ, Pape J, Kishida S, Kishida M, Jell G, Arnett TR, et al.diluted primary antibodies anti-MMP-2 (ab97779), anti-MMP-9 (ab38898), anti-RANK (ab222215), anti-RANKL (ab45039) and anti-osteocalcin (ab134418) were added to samples for 1 h at room temperature (Abcam, Cambridge,

(14) Fixation of free gingival grafts with cyanoacrylate glues: A histomorphometric and immunohistochemical studyThe Saudi Dental JournalDecember 1, 2021Dayrine Silveira de Paula, Lia Vila Real Lima, Roberta Barroso Cavalcante, Paulo GoberlÃ¢nio de Barros Silva, Ana Paula Negreiros Nunes Alves, Bruno Rocha da Silva(α-SMA) (1: 200, ab32575, Abcam®), anti-nuclear activator receptor kappa B ligand (RANK-L) (1: 200, ab45039, Abcam®), anti-osteoprotegerin (OPG) (1: 250, ab73400, Abcam®), anti-fibroblast growth factor (FGF)

(15) Curculigoside Protects against Titanium Particle-Induced Osteolysis through the Enhancement of Osteoblast Differentiation and Reduction of Osteoclast FormationJournal of Immunology ResearchJuly 4, 2021Fangbing Zhu, Jianyue Wang, Yueming Ni, Wei Yin, Qiao Hou, Yingliang Zhang, Shigui Yan, Renfu Quan(ab13847, Abcam), caspase-9 (ab32539, Abcam), SIRT1 (ab110304, Abcam), BMP-2 (ab214821, Abcam), RANKL (ab45039, Abcam), OPG (ab73400, Abcam), IκBα (ab32518, Abcam), p-IκBα (AF2002, Affinity), p65 (ab207297, Abcam),

(16) Effects of WNT1 c.110 T>C and c.505G>T mutations on osteoblast differentiation via the WNT1/β-catenin signaling pathwayJournal of orthopaedic surgery and researchJune 2, 2021Zhang B, Li R, Wang W, Zhou X, Luo B, Zhu Z, Zhang X, Ding A.(ab32391, Abcam, USA), p-GSK-3β (9323 s, Cell Signaling Technology), BMP2 (9323 s, Proteintech, China), and RANKL (ab45039, Abcam, USA) antibodies and corresponding HRP-conjugated secondary antibodies. The blots were visualized

(17) Diabetes mellitus accelerates the progression of osteoarthritis in streptozotocin-induced diabetic mice by deteriorating bone microarchitecture, bone mineral composition, and bone strength of subchondral boneAnnals of Translational MedicineMay 1, 2021Hua-Jun Wang et al.against osteoprotegerin (OPG) (ab203061) and receptor activator for nuclear factor‐κ B ligand (RANKL) (ab45039) from Abcam (Cambridge, UK), and Runt-related transcription factor 2 (RUNX-2) (ab92336), COL-1 (ab88147),

(18) Catalpol Protects Against High Glucose-Induced Bone Loss by Regulating Osteoblast FunctionFrontiers in PharmacologyMarch 10, 2021Lu Zhao, Wei Du, Dandan Zhao, Xueyan Ji, Yanfei Huang, Yong Pang, Kaijin Guo, Xiaoxing YinCompany. The OPN (ab214050), type I collagen (ab34710), osteocalcin (ab93876), OPG (ab203061), and RANKL (ab45039) antibody were purchased from Abcam (Cambridge, MA). Glucose (47829), streptozotocin (v900890), and

(19) Radiation induces primary osteocyte senescence phenotype and affects osteoclastogenesis in vitroInternational Journal of Molecular MedicineMarch 5, 2021Yuyang Wang, Linshan Xu, Jianping Wang, Jiangtao Bai, Jianglong Zhai, Guoying Zhu1:1,000), P16 (cat. no. ab51243, Abcam; 1:1,000), P21 (cat. no. ab188224, Abcam; 1:1,000), RANKL (cat. no. ab45039, Abcam; 1:1,000), OPG (cat. no. ab183910, Abcam; 1:1,000), SOST (cat. no. ab63097, Abcam; 1:1,000) or

(20) RANK, RANKL, and OPG in Dentigerous Cyst, Odontogenic Keratocyst, and Ameloblastoma: A Meta-AnalysisBrazilian Dental JournalFebruary 1, 2021Igor Felipe Pereira Lima, Felipe Rodrigues de Matos, Ítalo de Macedo Bernardino, Ingrede Tatiane Serafim Santana, Walbert de Andrade Vieira, Cauane Blumenberg, Walter Luiz Siqueira, Luiz Renato ParanhosOne study (26) used primary antibodies from mice for RANK (AB13918 - Abcam Inc. Cambridge) and RANKL (AB45039 - Abcam Inc. Cambridge), and primary antibodies from rabbits for OPG (AB9986 - Abcam Inc. Cambridge).

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Anti-RANKL antibody [12A668] - BSA and Azide free from Abcam

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Anti-RANKL antibody [12A668] - BSA and Azide free from Abcam

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