Anti-NAK/TBK1 antibody [EP611Y] ab40676 from Abcam

Product Specs
ItemAnti-NAK/TBK1 antibody [EP611Y]
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab40676
Antibody TypePrimary
Quantity10 UL, 40 UL, 100 UL
ApplicationsImmunocytochemistry/ Immunofluorescence, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot
IsotypeIgG
CloneEP611Y
ClonalityMonoclonal
HostRabbit
Conjugate/TagUnconjugated
Research AreaEpigenetics
Gene NameTBK1
ValidationKnockOut Validated
ReactivityHuman, Mouse, Rat
TargetNAK/TBK1

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Abcam

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Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) The Gut Microbiota of Pregnant Rats Alleviates Fetal Growth Restriction by Inhibiting the TLR9/MyD88 PathwayJournal of Microbiology and BiotechnologySeptember 28, 2023Hui Tang, Hanmei Li, Dan Li, Jing Peng, Xian Zhang, Weitao Yangab16667), MMP9 (1:1000 dilution, Abcam, ab228402), TRAF3 (2 μg/ml, Abcam, ab36988), TBK1 (1: 5000, Abcam, ab40676), IRF3 (1: 1000, Abcam, ab238521), p-IRF3 (1: 5000, Abcam, ab76493), NF-κBp65 (1:1000, Proteintech,

(2) Neutrophil extracellular traps contribute to immunothrombosis formation via the STING pathway in sepsis-associated lung injuryCell death discoveryAugust 25, 2023Zhu S, Yu Y, Qu M, Qiu Z, Zhang H, Miao C, Guo K.against MPO (1:1000, ab208670), TF (1:1000, ab189483, ab228968), STING (1:1000, ab239074), TBK1 (1:1000, ab40676), TLR1 (1:1000, ab68158), TLR2 (1:1000, ab209216), TLR3 (1:1000, ab307442), TLR5 (1:1000, ab168382),

(3) Cholesterol removal improves performance of a model biomimetic system to co-deliver a photothermal agent and a STING agonist for cancer immunotherapyNature CommunicationsAugust 22, 2023Lin Li, Mengxing Zhang, Jing Li, Tiantian Liu, Qixue Bao, Xi Li, Jiaying Long, Leyao Fu, Zhirong Zhang, Shiqi Huang, et al.clone: EPR20529, dilution: 1:1000), anti-C3 (ab200999, clone: EPR19394, dilution: 1:1000), anti-TBK1 (ab40676, clone: EP611Y, dilution: 1:5000) and anti-β actin (ab8226, clone: mAbcam 8226, dilution: 1:1000) for western blot

(4) TBK1 Knockdown Alleviates Axonal Transport Deficits in Retinal Ganglion Cells Via mTORC1 Activation in a Retinal Damage Mouse ModelInvestigative ophthalmology & visual scienceJuly 3, 2023Ye M, Hu Y, Zhao B, Mou Q, Ni Y, Luo J, Li L, Zhang H, Zhao Y.Proteasome inhibitor MG132 (Calbiochem), cycloheximide (CHX; Sigma‐Aldrich). Antibodies: anti-NAK/TBK1 (ab40676; Abcam); anti-NAK/TBK1 (ab109272; Abcam); anti-USP9X (ab180191; Abcam); anti-synaptophysin (ab14692;

(5) Targeting TBK1 to overcome resistance to cancer immunotherapyNatureMarch 1, 2023Sun Y, Revach OY, Anderson S, Kessler EA, Wolfe CH, Jenney A, Mills CE, Robitschek EJ, Davis TGR, Kim S, et al.was presented in the figures. Antibodies. For western blotting, primary antibodies against TBK1 (#ab40676, Abcam), IKKε (#3416T, Cell Signaling), p-RIPK S166/T169 (#31122S, Cell Signaling), RIPK1 (#3493S, Cell Signaling

(6) A non-nucleotide agonist that binds covalently to cysteine residues of STINGCell Structure and FunctionFebruary 16, 2023Kentaro Matsumoto, Shenwei Ni, Hiroyuki Arai, Takashi Toyama, Yoshiro Saito, Takehiro Suzuki, Naoshi Dohmae, Kojiro Mukai, Tomohiko Taguchi1:1000), rabbit anti-phospho-IRF3 (4D4G, dilution 1:1000) (Cell Signaling Technology); rabbit anti-TBK1 (ab40676, dilution 1:1000) (Abcam); mouse anti-α-tubulin (DM1A, dilution 1:1000) (Sigma-Aldrich); Goat Anti-Rabbit IgG (H + L) Mouse/Human ads-HRP

(7) Neuroprotective Effects of Sodium Butyrate by Restoring Gut Microbiota and Inhibiting TLR4 Signaling in Mice with MPTP-Induced Parkinson's DiseaseNutrientsFebruary 13, 2023Guo TT, Zhang Z, Sun Y, Zhu RY, Wang FX, Ma LJ, Jiang L, Liu HD.Proteintech), rabbit anti-TLR4 antibody (1:1000, 19811-1-AP, Proteintech), rabbit anti-MyD88 antibody (1:1000, ab40676, Abcam), rabbit anti-IL-6 antibody (1:1000, K009385P, Solarbio), rabbit anti-TNF-α antibody (1:1000,

(8) c-Myb Dominates TBK1-Mediated Endotoxin Tolerance in Kupffer Cells by Negatively Regulating DTX4Journal of immunology researchJanuary 1, 2023Wu YL, Pan LH, Yi ZJ, Zhang WF, Gong JP.Name,Catalog numbers,Company c-Myb,ab226251,Abcam DTX4,ab140289,Abcam TBK1,ab40676,Abcam TBK1,ab109735,Abcam Phospho-TBK1/NAK (Ser172),ab109272,Abcam Phospho-TBK1/NAK (Ser172),"5,483",CST iNOS,ab178945,Abcam TNF-α,ab183218,Abcam Phospho-NF-κB

(9) Modulation of innate immune response to viruses including SARS-CoV-2 by progesteroneSignal Transduction and Targeted TherapyDecember 1, 2022Shan Su et al.PGR (8757), SRC (2109), p-SRCY419 (2101) and p-Tyrosine (9411S) (Cell signaling technology), TBK1 (ab40676), p-TBK1S172 (ab109272) and p-IRF3S386 (ab76493) (Abcam) were purchased from the indicated companies.

(10) Endothelial deletion of TBK1 contributes to BRB dysfunction via CXCR4 phosphorylation suppressionCell death discoveryOctober 28, 2022Zhao B, Ni Y, Zhang H, Zhao Y, Li L.12–48 h. Primary antibodies used for immunofluorescence analysis were as follows: anti-TBK1 (Abcam, ab40676), FITC-isolectin B4 (IB4) (MilliporeSigma, L2895), anti-CD31 (Santa Cruz Biotechnology, sc376764), anti-collagen

(11) Endocytosis triggers V-ATPase-SYK-mediated priming of cGAS activation and innate immune responseProceedings of the National Academy of Sciences of the United States of AmericaOctober 25, 2022Yang YL, Cao LB, He WR, Zhong L, Guo Y, Yang Q, Shu HB, Hu MM.ABclonal); mcGAS (31659, CST); hcGAS (15102, CST); SYK (13198, CST); p-SYKY525/526 (2710, CST); TBK1 (ab40676, Abcam); p-TBK1S172 (ab109272, Abcam); IRF3 (sc-33641, Santa Cruz); p-IRF3S396 (4947, CST); β-actin

(12) STING Contributes to Cancer-Induced Bone Pain by Promoting M1 Polarization of Microglia in the Medial Prefrontal CortexCancersOctober 22, 2022Zhang X, Li X, Wang W, Zhang Y, Gong Z, Peng Y, Wu J, You X.Tech, MA, USA), Phospho-NF-κB p65 (Ser536) (1:1000, 3036, Cell Signaling Tech, MA, USA), TBK1 (1:1000, ab40676, Abcam, Cambridge, UK), Phospho-TBK1/NAK (Ser172) (1:1000, 5483, Cell Signaling Tech, MA, USA), MHCII

(13) ALS-linked loss of Cyclin-F function affects HSP90Life science allianceSeptember 16, 2022Siebert A, Gattringer V, Weishaupt JH, Behrends C.,Santa Cruz,sc-56 Skp1,Cell Signaling,2156 STIP1,Abcam,ab126724 STUB-1/CHIP,Bethyl Laboratories,A301-572A TBK1/NAK,Abcam,ab40676 Tollip,Abcam,ab187198 Secondary ABs,, Anti-goat-HRP,Promega,"V8051, RRID: AB_430838" Anti-mouse-HRP,Promega,W402B Anti-rabbit-HRP,Promega,W401B Anti-rat-HRP,Sigma-Aldrich,"A-9037,

(14) Identification of highly specific antibodies for Serine/threonine-protein kinase TBK1 for use in immunoblot, immunoprecipitation and immunofluorescenceF1000ResearchAugust 24, 2022Walaa Alshafie, Maryam Fotouhi, Irina Shlaifer, Riham Ayoubi, Aled M. Edwards, Thomas M. Durcan, Peter S. McPherson, Carl LaflammeThermo Fisher Scientific,703154,2274494,AB_2848223,recombinant-mono,JM42-11,rabbit,0.50,"Wb, IF" Abcam,ab12116,GR3334526-1,AB_298856,monoclonal,108A429,mouse,1.00,Wb Abcam,ab40676,GR3275777-2,AB_776632,recombinant-mono,EP611Y,rabbit,1.48,"Wb, IF" Abcam,ab109735,GR3263881-3,AB_10863562,recombinant-mono,EPR2867(2)-19,rabbit,0.50,"Wb

(15) USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STINGCell death & diseaseAugust 6, 2022Karlowitz R, Stanifer ML, Roedig J, Andrieux G, Bojkova D, Bechtel M, Smith S, Kowald L, Schubert R, Boerries M, et al.(GAPDH) (5G4cc, HyTest, Turku, Finland), mouse anti-Vinculin (#V9131-100UL, Merck), rabbit anti-TBK1 (ab40676, Abcam), rabbit anti-phospho-TBK1 (ab109272, Abcam), rabbit anti-Histone H2B (#07-371, Merck), mouse

(16) Extracellular Nucleotides and Histamine suppress TLR3- and RIG-I mediated release of antiviral Interferons from Human Airway Epithelial CellsThe Journal of ImmunologyMay 15, 2022Timothy S. Kountz, Assel Biyasheva, Robert P. Schleimer, Murali Prakriya(CST 8478), P-TBK1 (CST 5483), IRF3 (CST 11904), p65 (CST 8242), LaminA/C (CST 4777), T-TBK1 (Abcam ab40676), α-Tubulin (Abcam ab52866). Pharmacological tools were as follows: UTP (Sigma U6875), SLIGKV-NH2 (Tocris

(17) m6A-mediated modulation coupled with transcriptional regulation shapes long noncoding RNA repertoire of the cGAS-STING signalingComputational and Structural Biotechnology JournalApril 9, 2022Jinyi Song, Lele Zhang, Chenhui Li, Munire Maimaiti, Jing Sun, Jiameng Hu, Lu Li, Xiang Zhang, Chen Wang, Haiyang HuWestern blot analysis. The following antibodies were used: anti-STING (9664S, Cell Signaling), anti-TBK1 (ab40676, Abcam), anti-IRF3 (D83B9, Cell Signaling), anti-GAPDH (sc-32233, Santa Cruz Biotechnology), anti-Phaspho-STING

(18) PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensationNature communicationsMarch 23, 2022Gu H, Yang J, Zhang J, Song Y, Zhang Y, Xu P, Zhu Y, Wang L, Zhang P, Li L, et al.79978, Cat# 31659 (Mouse specific), 1:1000) were from Cell Signaling Technology. Rabbit anti-TBK1 (Cat# ab40676, 1:1000) was from Abcam. Rabbit anti-PCBP2 (Cat# 15070-1-AP, 1:1000) was from Proteintech. Mouse anti-PCBP2

(19) The RNA helicase DDX3 promotes IFNB transcription via enhancing IRF-3/p300 holocomplex binding to the IFNB promoterScientific reportsMarch 10, 2022Saikruang W, Ang Yan Ping L, Abe H, Kasumba DM, Kato H, Fujita T.purified mouse anti-IRF-3 antibody (Go-ChIP) were purchased from BioLegend. Rabbit monoclonal anti-TBK1 (ab40676) was purchased from Abcam. Rabbit monoclonal anti-phospho TBK1 (Ser172) (5483), rabbit monoclonal anti-IRF-3

(20) Specific association of TBK1 with the trans-Golgi network following STING stimulationCell Structure and FunctionMarch 8, 2022Haruka Kemmoku, Yoshihiko Kuchitsu, Kojiro Mukai, Tomohiko Taguchi(4D4G, dilution 1:1,000), rabbit anti-Rab11 (D4F5, 1:100) (Cell Signaling Technology); rabbit anti-TBK1 (ab40676, dilution 1:1,000 for western blot and dilution 1:200 for immunofluorescence) (Abcam); mouse anti-α-tubulin

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Anti-NAK/TBK1 antibody [EP611Y] from Abcam

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Anti-NAK/TBK1 antibody [EP611Y] from Abcam

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