Anti-HEXIM1 antibody ab25388 from Abcam

Product Specs
ItemAnti-HEXIM1 antibody
CompanyAbcam
Price Pricing Info Supplier Page View Company Product Page
Catalog Numberab25388
Antibody TypePrimary
HostRabbit
ApplicationsImmunocytochemistry/ Immunofluorescence, Immunoprecipitation, Western blot
IsotypeIgG
ClonalityPolyclonal
Quantity100 UG
Conjugate/TagUnconjugated
Concentration1 mg/ml
Research AreaEpigenetics
Gene NameHEXIM1
ReactivityHuman
TargetHEXIM1

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) 7SK methylation by METTL3 promotes transcriptional activityScience advancesMay 10, 2023Perez-Pepe M, Desotell AW, Li H, Li W, Han B, Lin Q, Klein DE, Liu Y, Goodarzi H, Alarcón CR.endogenous protein IP, we performed the same protocol as in Flag-IPs, but 10 g of rabbit α-HEXIM1 (ab25388, Abcam) or rabbit α-LARP7 (ab134746, Abcam) antibodies was incubated with protein A bead (Dynabeads

(2) TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphomaNature CommunicationsSeptember 27, 2022Tatiana Erazo et al.1:2000), H3R2me2 (cat. ab194684, dilution 1:1000), H4R3me2 (cat. ab5823, dilution 1:500), HEXIM1 (cat. ab25388, dilution 1:1000) and NOXA (cat. ab13654, dilution 1:500) were purchased from Abcam. P53 (cat. 2527,

(3) CDK9 activity switch associated with AFF1 and HEXIM1 controls differentiation initiation from epidermal progenitorsNature communicationsJuly 29, 2022Lloyd SM, Leon DB, Brady MO, Rodriguez D, McReynolds MP, Kweon J, Neely AE, Blumensaadt LA, Ho PJ, Bao X.conjugated to 10 µL beads in 250 µL total volume) for HA-CDK9, rabbit polyclonal anti-HEXIM1 (Abcam, ab25388, 3 µL conjugated to 10 µL beads in 250 µL total volume), and rabbit polyclonal AFF117 acquired from

(4) BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and ReplicationSSRN Electronic JournalMarch 30, 2022Akhil Bowry, Ann Liza Piberger, Eva Petermannanti-BRD4 [EPR5150(2)] Abcam Cat# ab128874, RRID:AB_11145462 Rabbit polyclonal anti-HEXIM1 Abcam Cat# ab25388, RRID:AB_2233058 Rabbit polyclonal anti-pS4/S8 RPA32 Bethyl Cat# A300-245A, RRID:AB_210547 Rabbit

(5) BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription ElongationCell reportsSeptember 22, 2020Edwards DS, Maganti R, Tanksley JP, Luo J, Park JJH, Balkanska-Sinclair E, Ling J, Floyd SR.324600, Thermo Fisher Scientific); DHX9 (1:1000WB, PA519542, Thermo Fisher Scientific); HEXIM1 (1:1000WB, ab25388, Abcam); Top2a (1:1000WB, ab52934, Abcam); Top 2b (1:1000, ab72334, Abcam); XPF (1:1000WB, ab76948,

(6) Selective Mediator dependence of cell-type-specifying transcriptionNature GeneticsJuly 1, 2020Martin G. Jaeger et al.(1:1000, Sigma Aldrich, T9026), CCNT1 (1:1000, Cell Signaling Technology, #81464S), HEXIM1 (1:1000, Abcam, ab25388), MED31 (1:500, Santa Cruz Biotechnology, sc-101189), pS2 Pol II (1:1000, Active Motif, #61083), Pol

(7) Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MSCellApril 3, 2020Daniel C. Factor et al.RRID:AB_141637 Donkey anti-rat AF488,Thermo Fisher Scientific,Cat#A-21208; RRID:AB_141709 HEXIM1,Abcam,Cat#ab25388; RRID:AB_2233058 MBP,Abcam,Cat#ab7349; RRID:AB_305869 NF,Covance,Cat#SMI311; RRID:AB_509991 NF,Covance,Cat#SMI312;

(8) Analysis of RNA binding properties of human Ku protein reveals its interactions with 7SK snRNA and protein components of 7SK snRNP complexBiochimieApril 1, 2020Olga Shadrina, Irina Garanina, Sergey Korolev, Timofei Zatsepin, Jeanne Van Assche, Fadoua Daouad, Clementine Wallet, Olivier Rohr, Marina Gottikhquantified by Bradford assay. Antibodies anti-Cdk9 (sc13130, Santa Cruz Biotechnology, USA), anti-HEXIM1 (ab25388, Abcam, USA), anti-Ku80 (ab119935, Abcam, USA), and rabbit IgG isotype control (Thermo Fisher Scientific,

(9) DDX5 potentiates HIV-1 transcription as a co-factor of TatRetrovirologyMarch 30, 2020Sithole N, Williams CA, Abbink TEM, Lever AML.following antibodies were from Santa Cruz: Myc (9E10), DDX17 (sc-398168), Abcam: HIV-Tat (ab43014), HEXIM1 (ab25388), Cyclin T1 (ab176702), CDK9 (ab6544), Rabbit Isotype matched control IgG (ab27478), Rabbit c-Myc (ab39688)

(10) BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and ReplicationCell reportsNovember 20, 2018Bowry A, Piberger AL, Rojas P, Saponaro M, Petermann E.anti-BRD3 (Abcam ab83478, 1:500), rabbit anti-BRD4 (Abcam ab128874, 1:1000), rabbit anti-HEXIM1 (Abcam ab25388,1:5000), rabbit anti-pS4/S8 RPA32 (Bethyl A300-245A, 1:1000), rabbit anti-pS317 CHK1 (Cell Signaling

(11) The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activationeLifeMay 30, 2018Tyler B Faust, Yang Li, Curtis W Bacon, Gwendolyn M Jang, Amit Weiss, Bhargavi Jayaraman, Billy W Newton, Nevan J Krogan, Iván D'Orso, Alan D Frankelfrom Aviva (ARP40847_P050) and Santa Cruz (sc-515209). HEXIM1 antibodies were purchased from Abcam (ab25388) and Everest (EB06964). CDK9 antibodies were purchased from Santa Cruz (sc-8338 and sc13130) and ProMab

(12) BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 RecruitmentMolecular CellJuly 6, 2017Georg E. Winter et al.anti-cleaved caspase 3 (Asp175),Cell Signaling Technology,Cat#9661S; RRID: AB_2341188 ,, Rabbit polyclonal anti-Hexim1,Abcam,Cat#ab25388; RRID: AB_2233058 ,, Mouse monoclonal anti-BRD3,Abcam,Cat#ab56342; RRID: AB_940633 ,, Rat monoclonal

(13) The 7SK snRNP associates with the little elongation complex to promote snRNA gene expressionThe EMBO JournalApril 3, 2017Sylvain Egloff, Patrice Vitali, Michael Tellier, Raoul Raffel, Shona Murphy, Tamás KissantiSer7P (4E12, ChromoTek), anti-PolII (sc-899X, Santa Cruz), anti-ZC3H8 (ab97821, Abcam), anti-HEXIM1 (ab25388, Abcam), antiLarp7 (ARP40847, Aviva System Biology), anti-MePCE (ab185991, Abcam), and anti-coilin (kind

(14) 7SK-BAF axis controls pervasive transcription at enhancersNature structural & molecular biologyMarch 1, 2016Flynn RA, Do BT, Rubin AJ, Calo E, Lee B, Kuchelmeister H, Rale M, Chu C, Kool ET, Wysocka J, et al.Ccnt1 (Santa Cruz, sc-10750), Cdk9 (Santa Cruz, sc-484), Brg1 (Santa Cruz, sc-17796), Hexim1 (Abcam, ab25388), Baf47 (Santa Cruz, sc-166165), Arid1a (Santa Cruz, sc-32761), Baf155 (Gift from G. Crabtree). Glycerol

(15) The Establishment of a Hyperactive Structure Allows the Tumour Suppressor Protein p53 to Function through P-TEFb during Limited CDK9 Kinase InhibitionPLOS ONEJanuary 8, 2016Thomas K. Albert, Claudia Antrecht, Elisabeth Kremmer, Michael Meisterernst

(16) SERPINE1 and SMA expression at the invasive front predict extracapsular spread and survival in oral squamous cell carcinomaBritish Journal of CancerNovember 25, 2014J Dhanda, A Triantafyllou, T Liloglou, H Kalirai, B Lloyd, R Hanlon, R J Shaw, D R Sibson, J M RiskSERPINE1 antibody (3785, American Diagnostica, Stamford, CT, USA) and 1 : 800 anti-HEXIM ChIP grade (ab25388, Abcam, Cambridge, UK). Primary antibody was omitted from negative controls. Immunohistochemistry-stained

(17) Transcriptional pause release is a rate-limiting step for somatic cell reprogrammingCell stem cellNovember 6, 2014Longqi Liu, Yan Xu, Minghui He, Meng Zhang, Fenggong Cui, Leina Lu, Mingze Yao, Weihua Tian, Christina Benda, Qiang Zhuang, Zhijian Huang, Wenjuan Li, Xiangchun Li, Ping Zhao, Wenxia Fan, Zhiwei Luo, Yuan Li, Yasong Wu, Andrew P Hutchins, Dongye Wang, Hung-Fat Tse, Axel Schambach, Jon Frampton, Baoming Qin, Xichen Bao, Hongjie Yao, Biliang Zhang, Hao Sun, Duanqing Pei, Huating Wang, Jun Wang, Miguel A Esteban

(18) Acute hypoxia affects P-TEFb through HDAC3 and HEXIM1-dependent mechanism to promote gene-specific transcriptional repressionNucleic acids researchAugust 1, 2014Safronova OS, Nakahama K, Morita I.phosphoserine 2 and phosphoserine 5 versions of Pol II were from Covance. HEXIM1 sheep (ab28016) and rabbit (ab25388) polyclonal antibodies were purchased from Abcam. Anti-HDAC1 (SA-401), anti-HDAC2 (SA-402) and anti-HDAC3

(19) A single point mutation in cyclin T1 eliminates binding to Hexim1, Cdk9 and RNA but not to AFF4 and enforces repression of HIV transcriptionRetrovirologyJuly 1, 2014Alona Kuzmina, Nina Verstraete, Sigal Galker, Maayan Maatook, Olivier Bensaude, Ran Taube

(20) 7SK small nuclear ribonucleoprotein complex is recruited to the HIV-1 promoter via short viral transcriptsFEBS lettersMay 2, 2014Mizutani T, Ishizaka A, Suzuki Y, Iba H.

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Anti-HEXIM1 antibody from Abcam

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Anti-HEXIM1 antibody from Abcam

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