Fig 1: Upregulation of CYP2B expression in DKO and PFIC5 livers. (A) Mouse liver sections from WT, DKO, QKO,Bsep+/-, andBsep-/- mice were stained with anti-BSEP (upper panel) and anti-CYP2B6 (lower panel) antibodies. Next, nuclei were counterstained with hematoxylin. Arrowheads indicate canalicular BSEP expression. (B) Cirrhotic liver sections from end-stage disease of patients with PFIC5 and PFIC2 were stained with anti-CYP2B6 antibody. (Inset) Parenchymal CYP2B6 staining. Arrowhead indicates positive CYP2B6 staining in a biliary tract.