Fig 2: A) Benign omentum without NNMT immunoreactivity (original magnification 200×). B) Metastatic high-grade endometrial carcinoma in the omentum with higher expression of NNMT in stroma compared to tumor (original magnification 400×). C) pAkt expression in omental metastatic tumor.

Fig 3: Disease-specific survival in patients with low and high metastatic NNMT expression (P = 0.039).

Fig 4: Representative presentation of NNMT protein expression in benign and malignant pancreatic tissues on tissue microarray sections by IHCRow 1 and 2 are NNMT staining observed at low (×40; bar = 500 µm) and high (×400; bar = 50 µm) magnification respectively. Column (A) Chronic pancreatitis with low expression of NNMT; Column (B) Paracancerous tissue with low NNMT expression; Column (C–E) show high NNMT expression in pancreatic cancer with well, moderate and poor differentiation respectively. IHC: immunohistochemistry; NNMT: Nicotinamide N-methyltransferase.

Fig 5: A). Primary tumor and stroma showing high NNMT expression (original magnification 400×). B) Diffuse strong nuclear p53 expression within the tumor cells of the same patient (original magnification 200×).