Fig 1: (A) Sur1 immunohistochemical detection localized in the cytoplasm and plasma membrane of renal cancer cells; double arrows indicate normal cells, and a single arrow indicates abnormally stained cells. Bar = 100 μm, 40X. (B) Kir6.1 immunohistochemical detection localized in the basal areas of cells (single arrow), normal cells (double arrows). Bar = 100 μm, 40X. (C) Abnormal Sur2A immunohistochemical detection localized in the cytoplasm and plasma membrane showing > 50% of positive cells vs. control. Bar = 100 μm, 40X. (D) Kir6.2 immunohistochemical localized in the basal areas of cells was found (single arrow) and in normal cells (double arrows). Bar = 100 μm, 10X. (E) Typical immunohistochemical staining with the primary mAb in the cytoplasm of the tubules used as a positive control for Sur2A in a non-cancer rat kidney section. Bar = 40 μm, 40X. (F) A rat renal section with no primary mAb was used as a negative control. Bar = 100 μm, 10X.
Fig 2: Differential expression genes are represented as boxplots of the ABCC8, ABCC9, KCNJ8, and KCNJ11 genes differentially expressed in several common tumor types. From left to right, the boxplots report the differential expression of tumor tissues compared to normal tissues of the following tumors: adrenal cancer, acute myeloid leukemia (aml), bladder cancer, breast cancer, colon cancer, esophageal carcinoma, liver cancer, lung adenocarcinoma, lung squamous cell carcinoma, ovarian serous cystadenocarcinoma, pancreatic adenocarcinoma, prostate adenocarcinoma, rectum adenocarcinoma, renal clear cell carcinoma, kidney chromophobe, kidney renal papillary cell carcinoma, skin cutaneous melanoma, testicular germ cell tumors, thyroid carcinoma, uterine carcinosarcoma, and uterine corpus endometrial carcinoma. Significant differences are observed from a Mann–Whitney U test (*p < 0.01). The four genes were downregulated in the great part of the considered cancer types of exception made for those marked with red arrows which are upregulated.
Supplier Page from Abcam for Anti-SUR1 antibody [N289/16]