Fig 1: Molecular docking map. (A) HIF1A (HIF-1a)-quercetin. (B) NFKBIA (I?Ba)-quercetin. (C) PPARG (PPAR?)-quercetin. (D) PPARG (PPAR?)-Vincoside lactam_qt. (E) PPARG (PPAR?)-Yohimbine. (F) PPARG (PPAR?)-Tetrahydroalstonine. The color indicates the type of residue: red—acidic, green—hydrophobic, purple—basic, and blue—polar. Protein–ligand interactions are indicated as lines between ligand atoms and protein residues: purple represents H-bonding to the protein backbone, while green represents pi-pi stacking interactions involving side chains of proteins. Gray spheres are used to mark ligand atoms exposed to solvent.
Fig 2: Effects of OJE on the histological change, serum levels, and activation of the NF-kB signaling pathway in mice with DSS-induced colitis. (A) H&E-stained colon sections (magnification 400×), histological score (n = 7–10), and (B) serum TNF-a, IL-6, IL-1ß and MCP-1 levels as pro-inflammatory cytokines (n = 6–7). (C) Protein levels of total- and phosphorylated-IkBa and -p65 were analyzed via Western blotting. The two lanes show the bands tested in tissue extracts from two representative animals. Protein density was quantified (n = 6). Values are the mean ± SEM. *** p < 0.001, NC vs. CON; # p < 0.05, ## p < 0.01, and ### p < 0.001, 5-ASA 50 mg/kg, OJE 50 mg/kg, OJE 100 mg/kg, OJE 200 mg/kg vs. DSS+NC.
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