Description
Product Characteristics:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Subcellular location: Cell membrane
Synonyms: Pgp, Mdr3, P-gp, Pgy3, Abcb4, Evi32, Mdr1a, Pgy-3, mdr-3, Multidrug resistance protein 1A, ATP-binding cassette sub-family B member 1A, P-glycoprotein 3, Abcb1a
Target Information: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]