Fig 2: Localization of NR4A2 in cartilage and synovium. NR4A2 protein was detected in paws of wild-type and hTNF-a mice at early (A,D), established (B,E), and late (C,F) stages of disease by immunohistochemistry. Isotype control was applied to a transgenic section from the late stage of disease (G). Representative images at 400× magnification are shown. Scoring of NR4A2 positive cells in synovium (H) and cartilage (I). Unpaired t-test, *p < 0.05, ***p < 0.0005.