Fig 1: SMER28 reduces microtubule polymerization dynamics. (a) U-2 OS cells expressing pEGFP-CLIP-170 were treated as indicated and at a frame rate of 1/sec recorded by spinning disk confocal microscopy 4 h later. Images depict CLIP-170 decorated microtubule plus-ends and tracks of microtubule plus ends detected for a time period of 30 s, indicated by colored lines. Crosses highlight MT plus end positions of respective frames. (b) Quantifications from at least three independent experiments are displayed as violin plots, with median; n = total number of videos analyzed; **P < 0.01, ****P < 0.0001 (one-way ANOVA).