Fig 1: miR-647 modulates drug resistance by reducing ANK2, FAK, MMP2, MMP12, CD44 and SNAIL1 expression. (A) TargetScan and microRNA.org were used to predict the target gene of miR-647. (B) ANK2, FAK, MMP2, MMP12, CD44 and SNAIL1 mRNA expression was detected by reverse transcription-quantitative polymerase chain reaction (n=4). (C) ANK2, FAK, MMP2, MMP12, CD44 and SNAIL1 protein expression was detected using western blotting (n=3). *P<0.05 vs. the LV-GFP and control groups. Data are presented as the means ± standard error of the mean. ANK2, ankyrin-B; CD44, cluster of differentiation 44; FAK, focal adhesion kinase; GFP, green fluorescent protein; miR-647, microRNA-647; MMP, matrix metalloproteinase; SNAIL1, snail family transcriptional repressor 1.