U0126, Selective MKK inhibitor ab120241 from Abcam

Product Specs
ItemU0126, Selective MKK inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab120241
Quantity1 MG, 5 MG, 25 MG
Purity0.98
Typeinhibitor

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Abcam

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Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

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Website: http://www.abcam.com

(1) Oncostatin M promotes lipolysis in white adipocytesAdipocyteDecember 31, 2022Pim P. van Krieken, Julian Roos, Pamela Fischer-Posovszky, Stephan Wueest, Daniel Konradphosphate-buffered saline (PBS)) for the indicated durations. Tofacitinib (S5001, Selleck Chemicals), U0126 (ab120241, Abcam) and Stattic (S7024, Selleck Chemicals) were dissolved in DMSO (vehicle) and administered to

(2) MAPK inhibitors protect against early‑stage osteoarthritis by activating autophagyMolecular medicine reportsDecember 1, 2021Lan CN, Cai WJ, Shi J, Yi ZJ.received an intra-articular injection of 0.1 ml (100 µmol/l) of U0126 (an ERK inhibitor; Abcam; cat. no. ab120241), SP600125 (a JNK inhibitor; Abcam; cat. no. ab120065) or SB203580 (a p38 inhibitor; Abcam; cat. no.

(3) Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signalingMolecular metabolismDecember 1, 2021van Krieken PP, Odermatt TS, Borsigova M, Blüher M, Wueest S, Konrad D.isoproterenol as indicated. For inhibitor experiments, cells were pre-treated for 1 h with 50 μmol/L U0126 (ab120241, Abcam, Cambridge, UK), 2 μmol/L Tofacitinib (CP-690550, LuBioScience GmbH, Zurich, Switzerland), or

(4) Cardiac macrophages prevent sudden death during heart stressNature communicationsMarch 26, 2021Sugita J, Fujiu K, Nakayama Y, Matsubara T, Matsuda J, Oshima T, Liu Y, Maru Y, Hasumi E, Kojima T, et al.the manufacturer’s instructions. A total of 10 µmol/l AG1478 (Wako, 017-20151, Japan), UO126 (Abcam, ab120241, USA) or FR180204 (Sigma, SML0320, USA) was added 1 h before supplementation with the indicated concentrations

(5) Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathwayAutophagyMay 1, 2019Niu C, Chen Z, Kim KT, Sun J, Xue M, Chen G, Li S, Shen Y, Zhu Z, Wang X, et al.pathway analysis, each pathway antagonist: compound C (10 μM; Abcam, ab120843) or GANT61 (20 μM; Abcam, ab120241) were given as pretreatment for 2 h every day before metformin administration. Figure 7. (Continued

(6) The Specific Inhibition of SOD1 Selectively Promotes Apoptosis of Cancer Cells via Regulation of the ROS Signaling NetworkOxidative medicine and cellular longevityJanuary 1, 2019Li X, Chen Y, Zhao J, Shi J, Wang M, Qiu S, Hu Y, Xu Y, Cui Y, Liu C, et al.alpha (phospho Y607) (Cat# ab182651), BAY117082 (Cat# ab141228), LY294002 (Cat# ab120243), U0126 (Cat# ab120241), Apoptotic DNA Ladder Detection Kit (Cat# ab66090), and Annexin V-FITC Apoptosis Staining/Detection Kit

(7) Leptin stimulates aromatase in the growth plate: limiting catch-up growth efficiencyThe Journal of endocrinologyJune 1, 2018Masarwi M, Shamir R, Phillip M, Gat-Yablonski G.mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinases (ERK1/2) (MEK1/2) inhibitor U0126 (cat. no. ab120241-5-B; 5 µM or 20 µM); phosphoinositide 3-kinase (PI3K) inhibitor LY294002 (cat. no. ab120243-5-B, 5 µM or

(8) CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat ModelInternational Journal of Molecular SciencesSeptember 29, 2016Weiwei Lu, Jia Shi, Jinming Zhang, Zhengtao Lv, Fengjing Guo, Hui Huang, Wentao Zhu, Anmin Chen(ab185722, ab41037), the aggrecan neo-epitope 374ARGSV (ab3773), PNCA (ab29), SB202190 (ab120638), U-0126 (ab120241), and C59 (ab142216) were purchased from Abcam (Cambridge, UK). Antibodies for ERK (#9102), phospho-ERK

(9) KRASG12 mutant induces the release of the WSTF/NRG3 complex, and contributes to an oncogenic paracrine signaling pathwayOncotargetAugust 16, 2016Yan Liu, Shu-Qing Wang, Yue-Hong Long, Su Chen, Yu-Feng Li, Jing-Hua Zhangmonoclonal anti-H3K9me2 antibody (ab1220) were obtained from Abcam. Wortmannin (ab120148) and U0126 (ab120241) were all purchased from Abcam. Plasmid construction and siRNA The coding regions of human KRAS, WSTF

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U0126, Selective MKK inhibitor from Abcam

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U0126, Selective MKK inhibitor from Abcam

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