Fig 1: The levels of MEK1/2, p-MEK1/2, MKK4, p-MKK4, ICAM1 and VCAM1 in the rat synovium tissue. The areal densities of MEK1/2, p-MEK1/2, MKK4, p-MKK4, ICAM1 and VCAM1-positive cells in full image were calculated by Motic Med 6.0 Digital Medical Image Analysis System. Data represent the mean SE of each group (n = 10). #p < 0.05 vs control group, ##p < 0.01 (independent samples t-test), *p < 0.05 vs model group; **p < 0.01 vs model group (one-way ANOVA followed by Dunnett’s t-test)