Fig 2: Abundance of TTR and S100A8 among the stages of AD. A) Representative images from western blot procedure to capture TTR and Tau bands, 17 kDa and 79 kDa respectively. No. of samples analyzed: CNh = 19, MCI = 21, AD = 17. Box plots with jitter across CNh, MCI, and AD groups show B) Tau expression normalized to loading control, Revert, CNh versus MCI t39 = 0.291, p = 0.437; CNh versus AD t35 = 0.278 p = 0.906; MCI versus AD t37 = 0.185 p = 0.241, C) normalized TTR, CNh versus MCI t39 = 0.007 p = 0.437; CNh versus AD t35 = 0.018 p = 0.019; MCI versus AD t37 = 0.845 p = 0.241. The whiskers on the boxplot represents the range of population and the horizontal line the median, *p < 0.05 and **p < 0.01.

Fig 3: HGF overexpression promotes the hepatocyte-like differentiation of grafted DPSCs. (A–L,A’–L’) Fluorescence microscopy images of hepatic tissue immunostained with anti-GFP (A,A’,E,E’,I,I’), anti-albumin (B,B’), anti-CK18 (F,F’), and anti-TTR (J,J’) and counterstained with DAPI (C,C’,G,G’,K,K’) and related merged fluorescence microscopy images (D,D’,H,H’,L,L’) in CCl4/DPSC-HGF (A–L) and CCl4/DPSC-HGF groups (A’–L’). A1-L1 and A’1-L’1 show magnified images of the outlined areas from the corresponding panels. (M-Q) Quantitative analyses of the number of GFP+ graft-derived cells (M), the percentage of resident GFP+ cells in total 1 × 106 grafted cells (N) and the percentages of albumin+ (O), CK18+ (P) and TTR+ (Q) cells in the GFP+ graft-derived cell population. Scale bar (A–L,A’–L’) = 100 µm. **P < 0.01; ***P < 0.001.