Fig 1: mRNA changes in response to different oxygen conditionsCAIX (A and B), (B) without the HBL-100 data), NHE1 (C) and V-ATPase subunits ATP6V1A (D) and ATP6V0A4 (E) mRNA levels were analyzed in cells cultured in 20% O2 (control, C), 0.5% O2 for 24h (acute hypoxia, AH) and 0.5% O2 for 10 weeks (chronic hypoxia, CH). Data expressed as mean ± SEM (n=3). *P=0.05, **P=0.01, ***P=0.001 and ****P=0.0001 (One-way ANOVA followed by Dunnett's multiple comparison test performed, comparing only the values within each cell line).