Fig 1: Comparison of the effects of the OGDHC regulators thiamine (Th) and TEGP on the expression of sirtuin 5 (A) and total or acetylated p53 (B) in cerebral cortex of the experimental rat groups. The expression is assessed by the western-blotting procedures described in Methods. Data for the different animal groups are expressed as percentage of the corresponding values determined in the non-operated (control, C) rats. The two-way ANOVA and post hoc Tukey’s test are used to determine statistical significance of differences. On the graphs, different p-values are shown by asterisks as described in Methods under Statistical Analysis. In the tables, significances (p = 0.05, in bold), according to the two-way ANOVA, are highlighted in gray. Only the statistically significant differences between the pairs of groups varying in a single factor (operation or treatment), are shown.