Fig 1: TSP1 and ERCC1 are involved in Txr1-mediated L-OHP sensitivity. (A) Txr1, TSP1 and ERCC1 mRNA levels in SGC7901 cells following siCON or siTxr1 lentiviral transfection and L-OHP treatment, detected using qPCR (***P<0.001 vs. CON). (B) Txr1, TSP1 and ERCC1 protein levels, examined by western blotting and using ß-actin as a loading control. (C) Txr1, TSP1 and ERCC1 mRNA levels in SGC-7901 cells following control or Txr1 lentiviral transfection and L-OHP treatment, detected by qPCR (***P<0.001 vs. CON). (D) Txr1, TSP1 and ERCC1 protein levels, examined by western blotting and using ß-actin as a loading control. Txr-1, taxol resistance gene 1; CON, negative control; Lv, recombinant lentivirus; TSP1, thrombospondin-1; ERCC, excision repair cross-complementing 1 protein; L-OHP, oxaliplatin; si, small interfering; qPCR, quantitative polymerase chain reaction.