Fig 1: Immunohistochemical expression of HELLS (A, B), ZIC2 (C, D) and ZIC5 (E, F) in prostate cancerHELLS is positive in a small subpopulation of tumor cells (arrowheads). ZIC2 is negative (C) or moderately positive in a high percentage of cells with both cytoplasmatic and nuclear expression (D). ZIC5 shows sporadic (E) or moderate (F) nuclear expression in scattered cells. Original magnifications, 400×.