Fig 1: Schematic illustration of multifunctional liposomes (EPSLP/TD) with hierarchical tumor targetability and pH-responsive capability to MCF-7 cell line. (I) Composition illustration of EPSLP/TD. (II) pH-responsive mechanism of EPSLP/TD in acidic tumor microenvironment. (III) EPR effect of EPSLP/TD after intravenous administration. (IV) EPSLP/TD was internalized into MCF-7 tumor cells via EphA10 receptor-mediated endocytosis, followed by endosome escape and target mitochondria, which induced the decrease of mitochondrial membrane potential, released of cytochrome c, activated Cas-9 and Cas-3, finally inducing cell apoptosis.