Fig 1: Inhibition of Notch1 increases serum cathepsin D and sFlt-1 and promote cleavage of 23-kD PRL to 16-kD PRL. A, Serum cathepsin D was detected by ELISA. B, Serum sFlt-1 was detected by ELISA. C, The cleavage of 23-kD PRL to 16-kD PRL in serum was determined by Western blot. All data were presented as mean ± SD (n = 6). *P < .05, *P < .05 vs indicated group. Comparisons between groups were analysed by two-way ANOVA with Bonferroni's post-test