Fig 1: The spatial functional characteristic of region-resolved MVs from human hearts(A) Four protein modules reveal MV proteomes specificity based on heart structure by co-expression analysis, including LA (n = 6), LV (n = 4), RA (n = 5), and RV (n = 5). The proteins with the one-way ANOVA p < 0.05 were regarded as statistically significant in the specific region. Red and blue boxes indicate proteins with increased and decreased abundance, respectively. Left panel: the co-expression patterns of the proteins in the four modules. Histogram on the right represents upregulated or downregulated proteins in the COVID-19 MVs of four heart regions, compared with those of the normal controls.(B) Clusters of proteins associated with similar biological processes of MVs in four heart regions are grouped according to the degree of enrichment. Circles of different sizes represent the number of genes. Gradient red boxes indicate the -log10 p value based on biological processes enrichment.(C) Immunohistochemistry of SF3B2 in the normal MVs of LA, LV, RA, and RV (scale bars: 100 µm).See also Figures S2 and S5.