Description
Product Characteristics: Function: Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K+ currents. Inhibited by Ba2+, quinine, quinidine, chloroform and halothane. Activated at alkaline pH. Tissue specificity: Highly expressed in pancreas. Not detectable in the other tissues tested. Subcellular location: Membrane, Multi-pass membrane protein.,Outward Rectifier,Potassium channel subfamily K member 16, TWIK-related alkaline pH -activated K(+) channel 1, 2P domain potassium channel Talk-1, TALK1
Target Information: The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]