Description
Product Characteristics: VPS26A, vacuolar protein sorting 26 homologue A (yeast), FLJ12930, HB58, Hbeta58, VPS26, Hbeta58 homolog, vacuolar protein sorting 26 (yeast homolog), vacuolar protein sorting 26 (yeast), vacuolar protein sorting 26 homolog A, vacuolar protein sorting 26 homolog A (S. pombe), PEP8A, OTTHUMP00000019721, vacuolar protein sorting 26 A
Target Information: This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]