Description
Product Characteristics: FUNCTION: This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. SUBUNIT: Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence. SUBCELLULAR LOCATION: Cell membrane, Peripheral membrane protein, Cytoplasmic side. Cell projection, growth cone membrane, Peripheral membrane protein, Cytoplasmic side. Cell junction, synapse. Note: Cytoplasmic surface of growth cone and synaptic plasma membranes.,Neuronal,Neuromodulin, growth-associated protein 43, protein F1, Basp2, B-50
Target Information: The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]