Description
Product Characteristics: TIRAP, toll-interleukin 1 receptor (TIR) domain containing adaptor protein, HGNC:17192, FLJ42305, Mal, wyatt, MyD88 adapter-like protein, TIR domain-containing adapter protein, Toll-interleukin 1 receptor (TIR) domain-containing adapter protein, Toll-interleukin 1 receptor domain-containing adaptor protein, adapter protein wyatt, OTTHUMP00000179130, Toll-like receptor adaptor protein
Target Information: The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants\, however, not all variants have been fully described. [provided by RefSeq, Jul 2008]