Fig 1: Development of renal failure due to adenine‐exposure. Biochemical evaluation of renal function: serum (A) creatinine, (B) phosphate, (C) FGF23, and (D) PTH levels in Sost −/− and control mice, exposed to adenine or control diet.
Fig 2: Development of cardiac vascular calcifications in Sost −/− mice with renal failure. Calcium content of (A) the aorta, (B) kidney, and (C) heart of Sost −/− and WT mice exposed to adenine or control diet, accompanied by representative images of von Kossa‐stained sections of the aorta, kidney and heart of Sost −/− mice (counterstained with H&E). (A) von Kossa staining was not able to reveal calcifications in the aortic tissue sections, (B) areas of calcification are present in the renal tubules, (C) cardiac calcifications are located in the vasculature.
Fig 3: Influence of CKD on bone metabolism in WT and Sost −/− mice. (A) Eroded perimeter, (B) bone area, (C) mineralized area (% of tissue area), (D) trabecular number, (E) osteoid area, (F) osteoblast perimeter (relative to the osteoid perimeter), (G) osteoid width, (H) trabecular thickness.
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