Fig 2: IMRGs expression verification and functional analysis.(A) In normal and PTC tissues, IHC staining was employed to analyze SFXN3 and TFR2 expression. (B) Verification of SFXN3-siRNA and TFR2-siRNA silencing efficacy at the mRNA level in TPC-1 cells. (C) Cell viability assay was measured after SFXN3 or TFR2 silencing. (D-E) mRNA and protein levels of iron-related proteins expression after SFXN3 or TFR2 silencing. DMT1 (-) IRE, divalent metal transporter 1 without iron responsive element; DMT1 (+) IRE, divalent metal transporter 1 with iron responsive element. *P < 0.05, **P < 0.01, ***P < 0.001.