Fig 1: XIST regulates adenoidal inflammation through the GRa-mediated NF-?B pathway. (A) Representative western blot images and (B) analyzed data demonstrated the inhibitory effect of the NF?B inhibitor EVP4593 and GRa on the XIST-induced increase in protein levels of Rel-B, c-Rel, P52, P50 and P65. (C) Reverse transcription-quantitative PCR data revealed the inhibitory effect of EVP4593 and GRa on the XIST-induced increase in the mRNA levels of inflammatory cytokines. (D) Analyzed data reported the inhibitory effect of EVP4593 and GRa on the XIST-induced increase in the protein levels of inflammatory cytokines as determined by ELISA. For IL-8, IL-6 and IL-1ß, n=5/group. For TNFa, n=6/group. #P<0.05 vs. the pcDNA/DMSO group and ?P<0.05 vs. the XIST/DMSO group. XIST, X inactivate-specific transcript; GRa, glucocorticoid receptor a; NF- ?B, nuclear factor ?-light-chain-enhancer of activated B cells; IL, interleukin; TNFa, tumor necrosis factor a.
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