Fig 1: CD40, PRF1, and EDN3 GSEA in GSE92324 dataset. (A-C) Results of GSEA analysis (GO). Listed CD40 (A), EDN3 (B) and PRF1 (C) in infertile samples using GSE92324 cohort. The top 5 signaling pathways are shown. (D-F) Results of GSEA analysis (KEGG). Listed CD40 (D), EDN3 (E) and PRF1 (F) in infertile samples using GSE92324 cohort. The top 5 signaling pathways are shown. GSEA, gene set enrichment analysis; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.
Fig 2: Validation in GSE92324 dataset. (A) Heat map of DEGs from GSE92324 dataset. (B) Venn diagram of the DEGs from GSE92324 dataset and the 17 candidate core genes. (C) CD40, EDN3, and PRF1 expressions in GSE92324 dataset between infertile and control groups. ROC curves of selected differentially expressed genes in the GSE92324 dataset: CD40 (D), EDN3 (E) and PRF1 (F). DEG, differentially expressed gene; IF, implantation failure; ROC, receiver operating characteristic; AUC, area under the curve.
Fig 3: Validation in GSE120103 dataset. (A-C) Box plots of three DEGs in GSE120103 dataset. Three genes included CD40 (A), EDN3 (B) and PRF1 (C). (D-F) ROC curves of selected differentially expressed genes in the GSE120103 dataset. The 3 genes included CD40 (D), EDN3 (E), and PRF1 (F). DEG, differentially expressed genes; ROC, receiver operating characteristic; AUC, area under the curve.
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