Fig 1: Relationship between Gab2 and CrkII and survival rate of patients with ovarian cancer. A Relationship between Gab2 and OS in patients. B Relationship between Gab2 and PFS in patients. C Relationship between CrkII and OS in patients. D Relationship between CrkII and PFS in patients
Fig 2: Expression of Gab2 and CrkII in ovarian cancer cell lines. A Western Blot was used to analysis of Gab2 and CrkII expression in ovarian cancer cell lines (A2780, SKOV3 and HO8910) and ovarian surface epithelial cells (IOSE80). B The expression of Gab2 in A2780 and SKOV3 transfected with Gab2 siRNA was elevated. C Evaluating the expression level of Gab2 in SKOV3 and A2780 cells were transfected with Gab2 overexpression virus. D The expression of CrkII in A2780 and SKOV3 transfected with CrkII knockdown virus was tested. E Testing the expression of CrkII in A2780 and SKOV3 were transfected with CrkII overexpression plastid
Fig 3: Effect of Gab2 on the biological behaviour of ovarian cancer cells. A Gab2 affects the migration ability of ovarian cancer cells. B Gab2 affects the proliferation of ovarian cancer cells. C Gab2 affects the sensitivity of ovarian cancer cells to carboplatin
Fig 4: Gab2 affects the biological function of ovarian cancer cells through CrkII. A Co-IP was employed to determine the relationship between Gab2 and CrkII in A2780 and SKOV3. B Knockdown of CrkII reversed the migration of ovarian cancer cells induced by Gab2 overexpression. C Knockdown of CrkII reversed the proliferation of ovarian cancer cells induced by Gab2 overexpression. D The effect of Gab2 on the chemosensitivity of ovarian cancer cells depends on CrkII
Fig 5: The expressions of Gab2 and CrkII in ovarian cancer were detected by immunohistochemistry. A Typical diagram of Gab2 immunohistochemical results (above: ovarian cancer tissue, below: adjacent tissues). B Expression of Gab2 in ovarian cancer tissue and adjacent tissues. C Typical diagram of CrkII immunohistochemical results (above: ovarian cancer tissue, below: adjacent tissues). D Expression of CrkII in ovarian cancer tissue and adjacent tissues. E The relationship between Gab2 and CrkII. The X-axis and Y-axis represent the comprehensive score of Gab2 and CrkII expression in ovarian cancer tissues, respectively
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