Fig 1: Identification of extracellular vesicles isolated from serum (A) the morphological characteristics of extracellular vesicles was observed by transmission electron microscope (TEM) (B) the diameter distribution and intensity of extracellular vesicles were analyzed through nano particle tracking analysis (NTA) (C) Extracellular vesicles specitic marker proteins (CD9, CD81 and TSG101) were detected by Western blotting.